Fetal lactic dehydrogenase variation in normal pregnancy and in cases of severe intra-uterine growth restriction

被引:3
作者
Verspyck, E
Gaillard, G
Parnet, F
Marret, S
Marpeau, L
机构
[1] Rouen Univ Hosp, Dept Obstet & Gynaecol, Rouen, France
[2] St Antoine Univ Hosp, Dept Obstet & Gynaecol, Paris, France
[3] Perinatal Haemobiol Ctr, Paris, France
[4] Rouen Univ Hosp, Dept Paediat, Rouen, France
关键词
cordocentesis; small for gestational age; fetal lactic dehydrogenase; fetal distress;
D O I
10.1002/(SICI)1097-0223(199903)19:3<229::AID-PD511>3.3.CO;2-B
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Physiological and pathological fetal levels of lactic dehydrogenase (LDH), including its five different iso-enzymes are still poorly known. Our objectives were to compare total LDH levels and its five iso-enzymes between a control group of healthy fetuses and a group of fetuses with severe intra-uterine growth restriction (IUGR), and to determine the biochemical associations and the prognostic value of elevated LDH activity in fetuses with IUGR. Total LDH levels, haematologic values and liver enzyme activities were measured in 108 healthy fetuses from 17 to 37 weeks of gestation and in 44 fetuses with severe IUGR. Total fetal LDH in plasma from the healthy fetuses were constant throughout pregnancy (mean (SD) = 305.09 (46.97)). Total LDH values in plasma significantly increased in cases of IUGR (p = 0.003), and the degree of increase was significantly correlated with fetal erythroblastosis (n = 44, r = 0.80, p <0.001). LDH 5 significantly decreased in the IUGR group (p = 0.03). Total LDH values strictly above 400 IU/l (a value equal to the mean + 2 SD in the healthy fetus group) were found to be significantly associated with thrombocytopenia (p <0.001), erythroblastosis (p = 0.008) and an increase in AST value (p = 0.03). These results suggest that the fetal LDH value in plasma is a useful biological marker for severe chronic distress. Copyright (C) 1999 John Wiley & Sons, Ltd.
引用
收藏
页码:229 / 233
页数:5
相关论文
共 16 条
  • [1] OBSTETRIC VARIABLES PREDICTING SURVIVAL OF THE IMMATURE NEWBORN (LESS-THAN-OR-EQUAL-TO-1000 GM) - A 5-YEAR EXPERIENCE AT A SINGLE PERINATAL CENTER
    AMON, E
    SIBAI, BM
    ANDERSON, GD
    MABIE, WC
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1987, 156 (06) : 1380 - 1389
  • [2] BERGMEYER HU, 1978, CLIN CHEM, V24, P58
  • [3] PHYSIOLOGY AND MANAGEMENT OF INTRAUTERINE GROWTH-RETARDATION - A BIOLOGIC APPROACH WITH FETAL BLOOD-SAMPLING
    COX, WL
    DAFFOS, F
    FORESTIER, F
    DESCOMBEY, D
    AUFRANT, C
    AUGER, MC
    GASCHARD, JC
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 159 (01) : 36 - 41
  • [4] ROLE OF UMBILICAL DOPPLER VELOCIMETRY IN THE BIOPHYSICAL ASSESSMENT OF THE GROWTH-RETARDED FETUS - ANSWERS FROM NEONATAL MORBIDITY AND MORTALITY
    FERRAZZI, E
    VEGNI, C
    BELLOTTI, M
    BORBONI, A
    DELLAPERUTA, S
    BARBERA, A
    [J]. JOURNAL OF ULTRASOUND IN MEDICINE, 1991, 10 (06) : 309 - 315
  • [5] BLOOD-CHEMISTRY OF NORMAL HUMAN FETUSES AT MIDTRIMESTER OF PREGNANCY
    FORESTIER, F
    DAFFOS, F
    RAINAUT, M
    BRUNEAU, M
    TRIVIN, F
    [J]. PEDIATRIC RESEARCH, 1987, 21 (06) : 579 - 583
  • [6] SERUM ENZYME-ACTIVITIES IN FULL-TERM ASPHYXIATED AND HEALTHY NEWBORNS - ENZYME-KINETICS DURING THE FIRST 144 HOURS OF LIFE
    LACKMANN, GM
    TOLLNER, U
    MADER, R
    [J]. ENZYME & PROTEIN, 1993, 47 (03) : 160 - 172
  • [7] Leroy B, 1971, Rev Fr Gynecol Obstet, V66, P391
  • [8] LOTT JA, 1980, CLIN CHEM, V26, P1241
  • [9] LACTATE METABOLISM IN NORMAL AND GROWTH-RETARDED HUMAN FETUSES
    MARCONI, AM
    CETIN, I
    FERRAZZI, E
    FERRARI, MM
    PARDI, G
    BATTAGLIA, FC
    [J]. PEDIATRIC RESEARCH, 1990, 28 (06) : 652 - 656
  • [10] Moss DW, 1986, TXB CLIN CHEM, P678