Impact of the Flavonoid Quercetin on β-Amyloid Aggregation Revealed by Intrinsic Fluorescence

被引：24

作者：

Alghamdi, Abeer ^{[1
]}

Birch, David J. S. ^{[1
]}

Vyshemirsky, Vladislav ^{[2
]}

Rolinski, Olaf J. ^{[1
]}

机构：

[1] Univ Strathclyde, Scottish Univ Phys Alliance, Dept Phys, Photophys Grp,Ctr Mol Nanometrol, Glasgow City G4 0NG, Scotland

[2] Univ Glasgow, Sch Math & Stat, Glasgow City G12 8QQ, Scotland

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2022年 / 126卷 / 38期

关键词：

ALZHEIMERS-DISEASE; OXIDATIVE STRESS; FIBRIL FORMATION; THIOFLAVIN T; IN-VITRO; ANTIOXIDANT; PEPTIDE; MODEL;

D O I：

10.1021/acs.jpcb.2c02763

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We report the effects of quercetin, a flavonoid present in the human diet, on early stage beta-amyloid (A beta) aggregation, a seminal event in Alzheimer's disease. Molecular level changes in A beta arrangements are monitored by time-resolved emission spectral (TRES) measurements of the fluorescence of A beta's single tyrosine intrinsic fluorophore (Tyr). The results suggest that quercetin binds beta-amyloid oligomers at early stages of their aggregation, which leads to the formation of modified oligomers and hinders the creation of beta-sheet structures, potentially preventing the onset of Alzheimer's disease.

引用

页码：7229 / 7237

页数：9

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