Microparticles for intranasal immunization

被引：79

作者：

Vajdy, M ^{[1
]}

O'Hagan, DT ^{[1
]}

机构：

[1] Chiron Vaccines, Emeryville, CA 94608 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2001年 / 51卷 / 1-3期

关键词：

mucosal delivery; nasal immunization; adjuvants; microparticles; DNA vaccines;

D O I：

10.1016/S0169-409X(01)00167-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Of the several routes available for mucosal immunization, the nasal route is particularly attractive because of ease of administration and the induction of potent immune responses, particularly in the respiratory and genitourinary tracts. However, adjuvants and delivery systems are required to enhance immune responses following nasal immunization. This review focuses on the use of microparticles as adjuvants and delivery systems for protein and DNA vaccines for nasal immunization. In particular we discuss our own work on poly(lactide co-glycolide) (PLG) microparticles with entrapped protein or adsorbed DNA as a vaccine delivery system. The possible mechanisms involved in the enhancement of immune responses through the use of DNA adsorbed onto PLG microparticles are also discussed. (C) 2001 Elsevier Science B.V. All rights reserved.

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页码：127 / 141

页数：15

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