PHARMACOKINETICS OF TRAMADOL AND O-DESMETHYLTRAMADOL IN LOGGERHEAD SEA TURTLES (CARETTA CARETTA)

被引：13

作者：

Norton, Terry M. ^{[1
]}

Cox, Sherry ^{[2
]}

Nelson, Steven E., Jr. ^{[1
]}

Kaylor, Michelle ^{[1
]}

Thomas, Rachel ^{[1
]}

Hupp, Amy ^{[1
]}

Sladky, Kurt K. ^{[3
]}

机构：

[1] Jekyll Isl Author, Georgia Sea Turtle Ctr, Jekyll Isl, GA 31527 USA

[2] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, Knoxville, TN 37996 USA

[3] Univ Wisconsin, Sch Vet Med, Dept Surg Sci, Madison, WI 53706 USA

来源：

JOURNAL OF ZOO AND WILDLIFE MEDICINE | 2015年 / 46卷 / 02期

关键词：

Analgesia; opioid; pain; ORAL TRAMADOL; METABOLITE; HYDROCHLORIDE; ANALGESIA;

D O I：

10.1638/2014-0158R1.1

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The objective of this study was to determine the pharmacokinetics of two orally administered doses of tramadol (5 and 10 mg/kg) and its major metabolite (O-desmethyltramadol) (M1) in loggerhead sea turtles (Caretta caretta). After oral administration, the half-life of tramadol administered at 5 and 10 mg/kg was 20.35 and 22.67 hr, whereas the half-life of M1 was 10.23 and 11.26 hr, respectively. The maximum concentration (C-max) for tramadol after oral administration at 5 mg/kg and 10 mg/kg was 373 and 719 ng/ml, whereas that of M1 was 655 and 1,376 ng/ml, respectively. Tramadol administered orally to loggerhead sea turtles at both dosages provided measurable plasma concentrations of tramadol and O-desmethyltramadol for several days with no adverse effects. Plasma concentrations of tramadol and O-desmethyltramadol remained >= 100 ng/ml for at least 48 and 72 hr when tramadol was administered at 10 mg/kg.

引用

页码：262 / 265

页数：4

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