The role of Snu114p during pre-mRNA splicing

被引：22
作者：
Frazer, Lily Novak [1 ]
Nancollis, Verity [1 ]
O'Keefe, Raymond T. [1 ]
机构：
[1] Univ Manchester, Fac Life Sci, Manchester M13 9PT, Lancs, England
来源：
BIOCHEMICAL SOCIETY TRANSACTIONS | 2008年 / 36卷
关键词：
elongation factor 2 (EF-2); GTPase; pre-mRNA splicing; Snu114p; spliceosome; U5 small nuclear ribonucleoprotein (U5 snRNP);
D O I：
10.1042/BST0360551
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pre-mRNA splicing is an essential step in gene expression where intron regions are removed and coding exon sequences are joined to form an mRNA for translation. Splicing is catalysed by an RNA-protein complex called the spliceosome. A number of spliceosome proteins are required for assembly and remodelling of the spliceosome with pre-mRNA to orient the splice sites correctly and catalyse the two steps of splicing. The spliceosome protein Snu114p is a GTPase that is related to the translation elongation factor EF-2. Snu114p plays a key role in spliceosome remodelling. in the present review, we briefly summarize the current knowledge of the function of Snu114p in pre-mRNA splicing and the role it plays in spliceosome dynamics.
引用
收藏
页码：551 / 553
页数：3
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