Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia

被引：9

作者：

Xiao, Zhijian ^{[1
,2
,3
,4
]}

Yang, Lin ^{[2
,3
,4
]}

Xu, Zefeng ^{[1
,2
,3
]}

Zhang, Yue ^{[2
,3
,4
]}

Liu, Liang ^{[2
,3
,4
]}

Nie, Ling ^{[2
,3
,4
]}

Li, Lin ^{[2
,3
,4
]}

Wang, Jianxiang ^{[2
,3
,4
,5
]}

Hao, Yushu ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 6, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

[4] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[5] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 2, Tianjin 300020, Peoples R China

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 08期

关键词：

acute myeloid leukemia; glutathione S-transferase; polymorphism; prognosis;

D O I：

10.1016/j.leukres.2007.10.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSST1) and glutahione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSST1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR = 1.88; P= 0.03) after the first course of chemotherapy, and was higher in GSST1+ group than in GSTT1 - group (OR = 2.20; P = 0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1288 / 1291

页数：4

共 50 条

[41] GSTT1, GSTM1, and GSTP1 polymorphisms and chemotherapy response in locally advanced breast cancer
Oliveira, A. L.
Rodrigues, F. F. O.
Santos, R. E.
Aoki, T.
Rocha, M. N.
Longui, C. A.
Melo, M. B.
GENETICS AND MOLECULAR RESEARCH, 2010, 9 (02) : 1045 - 1053
[42] Polymorphism of the glutathione S-transferase genes (GSTT1, GSTM1) in West Siberian patients with atopic bronchial asthma
Freidin, MB
Bragina, EY
Ogorodova, LM
Puzyrev, VP
MOLECULAR BIOLOGY, 2002, 36 (04) : 493 - 496
[43] Gene Dose Effects of GSTM1, GSTT1 and GSTP1 Polymorphisms on Outcome in Childhood Acute Lymphoblastic Leukemia
Borst, Louise
Buchard, Anders
Rosthoj, Susanne
Wesolowska, Agata
Wehner, Peder Skov
Wesenberg, Finn
Dalhoff, Kim
Schmiegelow, Kjeld
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2012, 34 (01) : 38 - 42
[44] Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan, China
Xiong, Da-Ke
Chen, Hong-Han
Ding, Xian-Ping
Zhang, Shao-Hong
Zhang, Jian-Hui
ASIAN JOURNAL OF ANDROLOGY, 2015, 17 (03) : 481 - 486
[45] Association between polymorphisms of glutathione S-transferase genes (GSTM1, GSTP1 and GSTT1) and breast cancer risk in a sample Iranian population
Hashemi, Mohammad
Eskandari-Nasab, Ebrahim
Fazaeli, Aliakbar
Taheri, Mohsen
Rezael, Hamzeh
Mashhadi, Mohammadali
Arbabi, Farshid
Kaykhaei, Mahmoud-Ali
Jahantigh, Mehdi
Bahari, Gholamreza
BIOMARKERS IN MEDICINE, 2012, 6 (06) : 797 - 803
[46] Germline polymorphisms of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis
Masatsugu Ueda
Eisaku Toji
Osamu Nunobiki
Naomi Sato
Shinji Izuma
Kiyo Torii
Yoshiaki Okamoto
Sadamu Noda
Human Cell, 2010, 23 : 119 - 125
[47] Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers
Zendehdel, Kazem
Bahmanyar, Shahram
McCarthy, Shane
Nyren, Olof
Andersson, Bjorn
Ye, Weimin
CANCER CAUSES & CONTROL, 2009, 20 (10) : 2031 - 2038
[48] Germline polymorphisms of glutathione-S-transferase GSTM1, GSTT1 and p53 codon 72 in cervical carcinogenesis
Ueda, Masatsugu
Toji, Eisaku
Nunobiki, Osamu
Sato, Naomi
Izuma, Shinji
Torii, Kiyo
Okamoto, Yoshiaki
Noda, Sadamu
HUMAN CELL, 2010, 23 (04) : 119 - 125
[49] Genetic polymorphisms of glutathione S-transferase genes GSTP1, GSTM1, and GSTT1 and risk of esophageal and gastric cardia cancers
Kazem Zendehdel
Shahram Bahmanyar
Shane McCarthy
Olof Nyren
Bjorn Andersson
Weimin Ye
Cancer Causes & Control, 2009, 20
[50] Potential risk modifications of GSTT1, GSTM1 and GSTP1 (glutathione-S-transferases) variants and their association to CAD in patients with type-2 diabetes
Ramprasath, Tharmarajan
Murugan, Ponniah Senthil
Prabakaran, Ashok Daniel
Gomathi, Pannerselvam
Rathinavel, Andiappan
Selvam, Govindan Sadasivam
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 407 (01) : 49 - 53

← 1 2 3 4 5 →