Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia

被引：9
|
作者：
Xiao, Zhijian [1 ,2 ,3 ,4 ]
Yang, Lin [2 ,3 ,4 ]
Xu, Zefeng [1 ,2 ,3 ]
Zhang, Yue [2 ,3 ,4 ]
Liu, Liang [2 ,3 ,4 ]
Nie, Ling [2 ,3 ,4 ]
Li, Lin [2 ,3 ,4 ]
Wang, Jianxiang [2 ,3 ,4 ,5 ]
Hao, Yushu [1 ,2 ,3 ]
机构：
[1] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 6, Tianjin 300020, Peoples R China
[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China
[3] Peking Union Med Coll, Tianjin 300020, Peoples R China
[4] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China
[5] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 2, Tianjin 300020, Peoples R China
来源：
LEUKEMIA RESEARCH | 2008年 / 32卷 / 08期
关键词：
acute myeloid leukemia; glutathione S-transferase; polymorphism; prognosis;
D O I：
10.1016/j.leukres.2007.10.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSST1) and glutahione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSST1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR = 1.88; P= 0.03) after the first course of chemotherapy, and was higher in GSST1+ group than in GSTT1 - group (OR = 2.20; P = 0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients. (C) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1288 / 1291
页数：4
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