Glutathione S-transferases (GSTT1 and GSTM1) genes polymorphisms and the treatment response and prognosis in Chinese patients with de novo acute myeloid leukemia

被引：10

作者：

Xiao, Zhijian ^{[1
,2
,3
,4
]}

Yang, Lin ^{[2
,3
,4
]}

Xu, Zefeng ^{[1
,2
,3
]}

Zhang, Yue ^{[2
,3
,4
]}

Liu, Liang ^{[2
,3
,4
]}

Nie, Ling ^{[2
,3
,4
]}

Li, Lin ^{[2
,3
,4
]}

Wang, Jianxiang ^{[2
,3
,4
,5
]}

Hao, Yushu ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 6, Tianjin 300020, Peoples R China

[2] Chinese Acad Med Sci, Blood Dis Hosp, Tianjin 300020, Peoples R China

[3] Peking Union Med Coll, Tianjin 300020, Peoples R China

[4] Chinese Acad Med Sci, Inst Hematol, State Key Lab Expt Hematol, Tianjin 300020, Peoples R China

[5] Chinese Acad Med Sci, Inst Hematol, Dept Clin Hematol 2, Tianjin 300020, Peoples R China

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 08期

关键词：

acute myeloid leukemia; glutathione S-transferase; polymorphism; prognosis;

D O I：

10.1016/j.leukres.2007.10.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We investigated the prognostic significance of genetic polymorphism for glutathione S-transferase theta 1 (GSST1) and glutahione S-transferase mu 1 (GSTM1) in 254 Chinese patients with de novo acute myeloid leukemia (AML) other than AML-M3. The early death rate after the initiation of chemotherapy was similar between the GSTT1+/GSTM1+ group and GSST1-/GSTM1- group. The complete remission (CR) rate was higher in GSTM1+ group than in GSTM1- group (OR = 1.88; P= 0.03) after the first course of chemotherapy, and was higher in GSST1+ group than in GSTT1 - group (OR = 2.20; P = 0.02) after the second course of chemotherapy. Overall survival and disease-free survival of CR patients in GSTT1 and GSTM1 double present group was better than in GSTT1- and/or GSTM1-group (P=0.03 and 0.02, respectively). Our preliminary results warrant testing of a larger number of patients. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：1288 / 1291

页数：4

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