Preparation and in vitro activities of naphthyl and indolyl ether derivatives of the FK-506 related immunosuppressive macrolide ascomycin

被引：33

作者：

Sinclair, PJ ^{[1
]}

Wong, F ^{[1
]}

Staruch, MJ ^{[1
]}

Wiederrecht, G ^{[1
]}

Parsons, WH ^{[1
]}

Dumont, F ^{[1
]}

Wyvratt, M ^{[1
]}

机构：

[1] MERCK RES LABS,DEPT IMMUNOL,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 18期

关键词：

D O I：

10.1016/0960-894X(96)00398-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of naphthyl- and indolyl-ethers of the immunosuppressive macrolide ascomycin using pentavalent bismuth reagents Is described. The in vitro activities of the aryl ether analogs are reported. The indole ether analogs show increased immunosuppressive activity in vitro relative to the parent macrolide. Copyright (C) 1996 Elsevier Science Ltd

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页码：2193 / 2196

页数：4

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