Bacteriocin-like inhibitory activities of seven Lactobacillus delbrueckii subsp bulgaricus strains against antibiotic susceptible and resistant Helicobacter pylori strains

被引：41

作者：

Boyanova, L. ^{[1
]}

Gergova, G. ^{[1
]}

Markovska, R. ^{[1
]}

Yordanov, D. ^{[1
]}

Mitov, I. ^{[1
]}

机构：

[1] Med Univ Sofia, Dept Med Microbiol, Zdrave St 2, Sofia 1431, Bulgaria

来源：

LETTERS IN APPLIED MICROBIOLOGY | 2017年 / 65卷 / 06期

关键词：

antibiotics; bacteriocins; Helicobacter; Lactobacillus; probiotics; LACTIC-ACID BACTERIA; ANTIBACTERIAL AGENTS; DAIRY-PRODUCTS; EVOLUTION; SYSTEMS;

D O I：

10.1111/lam.12807

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The aim of the study was to detect anti-Helicobacter pylori activity of seven Lactobacillus delbrueckii subsp. bulgaricus (GLB) strains by four cell-free supernatant (CFS) types. Activity of non-neutralized and non-heat-treated (CFSs1), non-neutralized and heat-treated (CFSs2), pH neutralized, catalase-treated and non-heat-treated (CFSs3), or neutralized, catalase- and heat-treated (CFSs4) CFSs against 18 H. pylori strains (11 of which with antibiotic resistance) was evaluated. All GLB strains produced bacteriocin-like inhibitory substances (BLISs), the neutralized CFSs of two GLB strains inhibited >81% of test strains and those of four GLB strains were active against >71% of antibiotic resistant strains. Two H. pylori strains were BLIS resistant. The heating did not reduce the CFS activity. Briefly, all GLB strains evaluated produced heat-stable BLISs, although GLB and H. pylori strain susceptibility patterns exhibited differences. Bacteriocin-like inhibitory substance activity can be an advantage for the probiotic choice for H. pylori infection control.

引用

页码：469 / 474

页数：6

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