Regio- and stereo-selective introduction of a bis(methoxycarbonyl)methyl group into the gamma-position of the piperidine skeleton

被引：12

作者：

Matsumura, Y ^{[1
]}

Yoshimoto, Y ^{[1
]}

Horikawa, C ^{[1
]}

Maki, T ^{[1
]}

Watanabe, M ^{[1
]}

机构：

[1] NAGASAKI UNIV,CTR INSTRUMENTAL ANAL,NAGASAKI 852,JAPAN

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/0040-4039(96)01208-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for a regioselective introduction of a bis(methoxycarbonyl)methyl group into the 4-position of the piperidine skeleton was explored, and this method was applied to the preparation of cis- and trans-2,4-disubstituted piperidines starting from 2-piperidinecarboxylic acid. The key steps in the method involved electrochemical oxidation of carbamates. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5715 / 5718

页数：4

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