Immunological Monitoring for Guidance of Preemptive Antiviral Therapy for Active Cytomegalovirus Infection in Allogeneic Stem-Cell Transplant Recipients: A Pilot Experience

被引：20

作者：

Solano, Carlos ^{[1
,2
]}

Benet, Isabel ^{[1
,2
]}

Jose Remigia, Maria ^{[1
]}

de la Camara, Rafael ^{[3
]}

Munoz-Cobo, Beatriz ^{[4
]}

Costa, Elisa ^{[4
]}

Angeles Clari, Maria ^{[4
]}

Bravo, Dayana ^{[4
]}

Amat, Paula ^{[1
]}

Navarro, David ^{[1
,4
,5
]}

机构：

[1] Hosp Clin Univ, Hematol & Med Oncol Serv, Valencia 46010, Spain

[2] Univ Valencia, Dept Med, Sch Med, Valencia, Spain

[3] Hosp La Zarzuela, Hematol Serv, Madrid, Spain

[4] Hosp Clin Univ, Microbiol Serv, Valencia 46010, Spain

[5] Univ Valencia, Dept Microbiol, Sch Med, Valencia 46010, Spain

来源：

TRANSPLANTATION | 2011年 / 92卷 / 04期

关键词：

CD4(+) T-CELLS; IFN-GAMMA CD8(+); IMMUNE-RESPONSES; CMV; RECONSTITUTION; MANAGEMENT; DNAEMIA; PP65; SCT;

D O I：

10.1097/TP.0b013e318224f263

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

引用

页码：E17 / E20

页数：4

共 12 条

[1] Evaluation of intervention strategy based on CMV-specific immune responses after allogeneic SCT [J].

Avetisyan, G. ;

Aschan, J. ;

Haegglund, H. ;

Ringden, O. ;

Ljungman, P. .

BONE MARROW TRANSPLANTATION, 2007, 40 (09) :865-869

[2] Quantification of DNA in plasma by an automated real-time PCR assay (cytomegalovirus PCR kit) for surveillance of active cytomegalovirus infection and guidance of preemptive therapy for allogeneic hematopoietic stem cell transplant recipients [J].

Gimeno, Concepcion ;

Solano, Carlos ;

Latorre, Jose C. ;

Hernandez-Boluda, Juan C. ;

Clari, Maria A. ;

Remigia, Maria J. ;

Furio, Santiago ;

Calabuig, Marisa ;

Tormo, Nuria ;

Navarro, David .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (10) :3311-3318

[3] Immune reconstitution to cytomegalovirus after allogeneic hematopoietic stem cell transplantation: impact of host factors, drug therapy, and subclinical reactivation [J].

Hakki, M ;

Riddell, SR ;

Storek, J ;

Carter, RA ;

Stevens-Ayers, T ;

Sudour, P ;

White, K ;

Corey, L ;

Boeckh, M .

BLOOD, 2003, 102 (08) :3060-3067

[4] Human cytomegalovirus-specific CD4+ and CD8+ T-cell reconstitution in adult allogeneic hematopoietic stem cell transplant recipients and immune control of viral infection [J].

Lilleri, Daniele ;

Fornara, Chiara ;

Chiesa, Antonella ;

Caldera, Daniela ;

Alessandrino, Emilio Paolo ;

Gerna, Giuseppe .

HAEMATOLOGICA, 2008, 93 (02) :248-256

[5] Management of CMV, HHV-6, HHV-7 and Kaposi-sarcoma herpesvirus (HHV-8) infections in patients with hematological malignancies and after SCT [J].

Ljungman, P. ;

de la Camara, R. ;

Cordonnier, C. ;

Einsele, H. ;

Engelhard, D. ;

Reusser, P. ;

Styczynski, J. ;

Ward, K. .

BONE MARROW TRANSPLANTATION, 2008, 42 (04) :227-240

[6] Would monitoring CMV immune responses allow improved control of CMV in stem cell transplant patients [J].

Ljungman, Per .

JOURNAL OF CLINICAL VIROLOGY, 2006, 35 (04) :493-495

[7] Enumeration of cytomegalovirus-specific interferonγ CD8+ and CD4+ T cells early after allogeneic stem cell transplantation may identify patients at risk of active cytomegalovirus infection [J].

Solano, Carlos ;

Benet, Isana ;

Clari, Maria A. ;

Nieto, Jose ;

de la Camara, Rafael ;

Lopez, Javier ;

Hernandez-Boluda, Juan C. ;

Remigia, Maria J. ;

Jarque, Isidro ;

Calabuig, Maria L. ;

Garcia-Noblejas, Ana ;

Alberola, Juan ;

Tamarit, Amparo ;

Gimeno, Concepcion ;

Navarro, David .

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2008, 93 (09) :1434-1436

[8] Clinical virology of cytomegalovirus infection following hematopoietic transplantation [J].

Solano, Carlos ;

Navarro, David .

FUTURE VIROLOGY, 2010, 5 (01) :111-124

[9] Lack of prompt expansion of cytomegalovirus pp65 and IE-1-specific IFNγ CD8+ and CD4+ T cells is associated with rising levels of pp65 antigenemia and DNAemia during pre-emptive therapy in allogeneic hematopoietic stem cell transplant recipients [J].

Tormo, N. ;

Solano, C. ;

Benet, I. ;

Clari, M. A. ;

Nieto, J. ;

de la Camara, R. ;

Lopez, J. ;

Lopez-Aldeguer, N. ;

Hernandez-Boluda, J. C. ;

Remigia, M. J. ;

Garcia-Noblejas, A. ;

Gimeno, C. ;

Navarro, D. .

BONE MARROW TRANSPLANTATION, 2010, 45 (03) :543-549

[10]

Tormo N, 2011, BONE MARROW TRANSPLA

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