Electroactive controlled release thin films

被引：113

作者：

Wood, Kris C. ^{[1
]}

Zacharia, Nicole S. ^{[2
]}

Schmidt, Daniel J. ^{[1
]}

Wrightman, Stefani N. ^{[1
]}

Andaya, Brian J. ^{[3
]}

Hammond, Paula T. ^{[1
]}

机构：

[1] MIT, Dept Chem Engn, Cambridge, MA 02139 USA

[2] MIT, Dept Mat Sci & Engn, Cambridge, MA 02139 USA

[3] Univ Rochester, Dept Chem Engn, Rochester, NY 14627 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2008年 / 105卷 / 07期

关键词：

drug delivery; layer-by-layer thin film; polymer; responsive materials; Prussian Blue;

D O I：

10.1073/pnas.0706994105

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We present the fabrication of nanoscale electroactive thin films that can be engineered to undergo remotely controlled dissolution in the presence of a small applied voltage (+1.25 V) to release precise quantities of chemical agents. These films, which are assembled by using a nontoxic, FDA-approved, electroactive material known as Prussian Blue, are stable enough to release a fraction of their contents after the application of a voltage and then to restabilize upon its removal. As a result, it is possible to externally trigger agent release, exert control over the relative quantity of agents released from a film, and release multiple doses from one or more films in a single solution. These electroactive systems may be rapidly and conformally coated onto a wide range of substrates without regard to size, shape, or chemical composition, and as such they may find use in a host of new applications in drug delivery as well as the related fields of tissue engineering, medical diagnostics, and chemical detection.

引用

页码：2280 / 2285

页数：6

共 34 条

[1] Controlled electrodissolution of polyelectrolyte multilayers:: A platform technology towards the surface-initiated delivery of drugs [J].