Interactions between the Re-Emerging Pathogen Corynebacterium diphtheriae and Host Cells

被引：19

作者：

Ott, Lisa ^{[1
]}

Moeller, Jens ^{[2
]}

Burkovski, Andreas ^{[2
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Dept Biol, Staudtstr 5, D-91058 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg, Microbiol Div, Staudtstr 5, D-91058 Erlangen, Germany

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 06期

关键词：

apoptosis; diphtheria; diphtheria toxin; mycolic acids; necrosis; pyroptosis; Shiga-like toxin; TELLURITE-RESISTANCE; TOXIN RECEPTOR; GROWTH-FACTOR; GASDERMIN D; DEATH; PILUS; APOPTOSIS; EPIDEMIOLOGY; CONTRIBUTES; BINDING;

D O I：

10.3390/ijms23063298

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Corynebacterium diphtheriae, the etiological agent of diphtheria, is a re-emerging pathogen, responsible for several thousand deaths per year. In addition to diphtheria, systemic infections, often by non-toxigenic strains, are increasingly observed. This indicates that besides the well-studied and highly potent diphtheria toxin, various other virulence factors may influence the progression of the infection. This review focuses on the known components of C. diphtheriae responsible for adhesion, invasion, inflammation, and cell death, as well as on the cellular signaling pathways activated upon infection.

引用

页数：17

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