Scale-up of Aerobic Stirred Bioreactors Using the Mixing Time Criteria 1. Simulated Broths

被引：0
|
作者：
Cascaval, D. [1 ]
Galaction, A. -I. [2 ]
Camarut, S. [1 ]
机构：
[1] Tech Univ Gh Asachi Iasi, Fac Chem Engn & Environm Protect, Dept Biochem Engn, Iasi 700050, Romania
[2] Univ Med & Pharm Gr T Popa Iasi, Fac Med Bioengn, Dept Biotechnol, Iasi 700454, Romania
来源：
CHEMICAL AND BIOCHEMICAL ENGINEERING QUARTERLY | 2011年 / 25卷 / 01期
关键词：
Stirred bioreactor; mixing time; scale-up; power input; shear force; FERMENTATION; YEASTS;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The paper is dedicated to the analysis of the scale-up of an aerobic stirred bioreactor from 4 L working volume to 40 L using the mixing time criterion, taking into account its required conditions and effects. Therefore, if the selected operating parameters allow obtaining similar values of mixing time in the larger bioreactor as in the reference one, it is possible to maintain also the specific power consumption by scaling-up. However, the shear forces in the larger bioreactor are amplified with 23 - 35 %, the most important increase being recorded for high viscous broths.
引用
收藏
页码：43 / 54
页数：12
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