Prenatal famine exposure and cognition at age 59 years

被引:46
作者
de Groot, Renate H. M. [2 ,3 ,4 ,5 ]
Stein, Aryeh D. [6 ]
Jolles, Jelle [3 ]
van Boxtel, Martin P. J. [4 ,5 ]
Blauw, Gerard-Jan [7 ]
van de Bor, Margot [8 ]
Lumey, L. H. [1 ]
机构
[1] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY 10032 USA
[2] Open Univ, Ctr Learning Sci & Technol, Heerlen, Netherlands
[3] Vrije Univ Amsterdam, Ctr Brain & Learning, AZIRE Res Inst, Fac Psychol & Educ, Amsterdam, Netherlands
[4] Maastricht Univ, Sch Mental Hlth & Neurosci, Div Cognit Disorders, Maastricht, Netherlands
[5] Maastricht Univ, Dept Psychiat & Neuropsychol, Maastricht, Netherlands
[6] Emory Univ, Hubert Dept Global Hlth, Rollins Sch Publ Hlth, Atlanta, GA 30322 USA
[7] Leiden Univ, Med Ctr, Dept Gerontol & Geriatr, NL-2300 RA Leiden, Netherlands
[8] Vrije Univ Amsterdam, Dept Hlth & Life Sci, Amsterdam, Netherlands
基金
美国国家卫生研究院;
关键词
Prenatal exposures; nutrition; mental development; developmental origins; Dutch famine; COLOR-WORD TEST; NORMATIVE DATA; PERFORMANCE; PREGNANCY; CHILDHOOD; NUTRITION; ADULTHOOD; EDUCATION; SEX; SCHIZOPHRENIA;
D O I
10.1093/ije/dyq261
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Background Despite the perceived importance of early life nutrition for mental development, few studies have related gestational undernutrition to later-life cognitive functioning. We investigated the consequences of gestational exposure to the Dutch famine of 1944-45 for cognitive functioning at the age of 59 years. Methods We recruited men and women who were (i) born in birth clinics in Amsterdam, Rotterdam and Leiden, between January 1945 and March 1946, whose mothers experienced famine during or immediately preceding pregnancy (n = 354); (ii) born in the same three institutions during 1943 and 1947, whose mothers did not experience famine during this pregnancy (n = 292); or (iii) same-sex siblings of those in the first two categories (n = 311). We assessed cognitive performance at the age of 59 years by means of a comprehensive test battery. Results All cognitive functioning test scores were within normal ranges for this age group. There were no differences in cognitive performance at the age of 59 years between individuals exposed to gestational undernutrition and those without this exposure. For the general cognitive index, a summary measure across six functional domains (mean 100, standard deviation (SD) 15 points), famine exposure was associated with a decrease of 0.57 points [95% confidence interval (95% CI) -2.41 to 1.28] points. Individuals exposed to famine in gestational weeks 1-10 had a cognitive functioning index 4.36 (95% CI 8.04-0.67) points lower than those without this exposure. Within-sibling-pair analyses gave consistent results. Conclusion We found no overall association between maternal exposure to acute famine in pregnancy and cognitive performance of the offspring at the age of 59 years, but cannot rule out an association specific to early pregnancy exposure.
引用
收藏
页码:327 / 337
页数:11
相关论文
共 47 条
  • [1] Effects of age on performance in a finger-precuing task
    Adam, JJ
    Pans, FGWC
    Teeken, JC
    van Loon, EM
    van Boxtel, MPJ
    Houx, PJ
    Jolles, J
    [J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY-HUMAN PERCEPTION AND PERFORMANCE, 1998, 24 (03) : 870 - 883
  • [2] [Anonymous], 1975, FAMINE HUM DEV DUTCH
  • [3] Effects of stunting, diarrhoeal disease, and parasitic infection during infancy on cognition in late childhood: a follow-up study
    Berkman, DS
    Lescano, AG
    Gilman, RH
    Lopez, S
    Black, MM
    [J]. LANCET, 2002, 359 (9306) : 564 - 571
  • [4] Prevention of neural-tube defects with folic acid in China
    Berry, RJ
    Li, Z
    Erickson, JD
    Li, S
    Moore, CA
    Wang, H
    Mulinare, J
    Zhao, P
    Wong, LYC
    Gindler, J
    Hong, SX
    Correa, A
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (20) : 1485 - 1490
  • [5] PERFORMANCE IN THE STROOP COLOR WORD TEST IN RELATIONSHIP TO THE PERSISTENCE OF SYMPTOMS FOLLOWING MILD HEAD-INJURY
    BOHNEN, N
    TWIJNSTRA, A
    JOLLES, J
    [J]. ACTA NEUROLOGICA SCANDINAVICA, 1992, 85 (02): : 116 - 121
  • [6] Burger GCE., 1948, Malnutrition and starvation in Western Netherlands
  • [7] De Bie S. E., 1987, Toward a standardization of questions concerning demographic variables in population studies
  • [8] Differences in cognitive performance during pregnancy and early motherhood
    De Groot, R. H. M.
    Vuurman, E. F. P. M.
    Hornstra, G.
    Jolles, J.
    [J]. PSYCHOLOGICAL MEDICINE, 2006, 36 (07) : 1023 - 1032
  • [9] Prenatal undernutrition and cognitive function in late adulthood
    de Rooij, Susanne R.
    Wouters, Hans
    Yonker, Julie E.
    Painter, Rebecca C.
    Roseboom, Tessa J.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (39) : 16881 - 16886