Traumatic experiences and cognitive profiles of schizophrenia cases influenced by the BDNF Val66met polymorphism

被引：2

作者：

Veras, Andre B. ^{[1
,2
,3
,4
,5
]}

Chao, Moses V. ^{[6
,7
,8
,14
]}

Getz, Mara ^{[9
]}

Goetz, Raymond ^{[10
]}

Cheniaux, Elie ^{[2
,11
]}

Lopes, Fabiana L. ^{[12
]}

Nardi, Antonio E. ^{[1
]}

Walsh-Messinger, Julie ^{[13
]}

Malaspin, Dolores ^{[3
,4
,5
]}

Kranz, Thorsten M. ^{[6
,7
,8
,14
]}

机构：

[1] Univ Catolica Dom Bosco, Translat Res Grp Mental Hlth GPTranSMe, Campo Grande, Brazil

[2] Fed Univ Rio de Janeiro UFRJ, Inst Psychiat, Rio De Janeiro, Brazil

[3] Mt Sinai Med Ctr, Icahn Sch Med, Dept Psychiat, New York, NY 10029 USA

[4] Mt Sinai Med Ctr, Icahn Sch Med, Dept Neurosci, New York, NY 10029 USA

[5] Mt Sinai Med Ctr, Icahn Sch Med, Dept Genet & Genom, New York, NY 10029 USA

[6] NYU, Dept Cell Biol, Skirball Inst Biomol Med, 550 1St Ave, New York, NY 10016 USA

[7] NYU, Dept Physiol & Neurosci, Skirball Inst Biomol Med, New York, NY USA

[8] NYU, Dept Psychiat, Skirball Inst Biomol Med, 550 1St Ave, New York, NY 10016 USA

[9] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA

[10] Columbia Univ, Dept Psychiat, New York, NY USA

[11] State Univ Rio de Janeiro UERJ, Rio De Janeiro, Brazil

[12] NIMH, Bethesda, MD 20892 USA

[13] Univ Dayton, Dept Psychol, Dayton, OH 45469 USA

[14] Univ Hosp Frankfurt, Dept Psychiat Psychosomat Med & Psychotherapy, Frankfurt, Germany

来源：

PSYCHIATRY RESEARCH | 2019年 / 271卷

关键词：

BDNF; Trauma; Schizophrenia; CHILDHOOD TRAUMA; RATING-SCALE; TRANSMISSION; PLASTICITY; FEATURES;

D O I：

10.1016/j.psychres.2018.11.029

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

The association of early trauma exposure with current cognition was examined in a research series of 56 schizophrenia cases with respect to the BDNF Va166Met polymorphism (rs6265, Val66Val, Val66Met, Met66Met), as met allele carriers have reduced neurotrophic activity. The Perceptual Organization Index had a significant negative correlation with trauma exposures only in met carriers, including early physical abuse, general trauma after age 18 years, and physical abuse. Within the Val66Val subgroup, there were no significant correlations between WAIS indices and traumatic experiences.

引用

页码：111 / 113

页数：3

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