Sustained Smad2 Phosphorylation Is Required for Myofibroblast Transformation in Response to TGF-β

被引：17

作者：

Ard, Shawn ^{[1
]}

Reed, Eleanor B. ^{[1
]}

Smolyaninova, Larisa V. ^{[2
]}

Orlov, Sergei N. ^{[2
,3
]}

Mutlu, Gokhan M. ^{[1
]}

Guzy, Robert D. ^{[1
]}

Dulin, Nickolai O. ^{[1
]}

机构：

[1] Univ Chicago, Chicago, IL 60637 USA

[2] Lomonosov Moscow State Univ, Moscow, Russia

[3] Siberian Med State Univ, Tomsk, Russia

来源：

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY | 2019年 / 60卷 / 03期

基金：

美国国家卫生研究院;

关键词：

GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX; ACTIVATION;

D O I：

10.1165/rcmb.2018-0252LE

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：367 / 369

页数：3

共 12 条

[1] Stretch-induced Activation of Transforming Growth Factor-β1 in Pulmonary Fibrosis [J].

Froese, Aaron R. ;

Shimbori, Chiko ;

Bellaye, Pierre-Simon ;

Inman, Mark ;

Obex, Steffen ;

Fatima, Safoora ;

Jenkins, Gisli ;

Gauldie, Jack ;

Ask, Kjetil ;

Kolb, Martin .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 194 (01) :84-96

[2] EFFECT OF ANTIBODY TO TRANSFORMING GROWTH-FACTOR-BETA ON BLEOMYCIN-INDUCED ACCUMULATION OF LUNG COLLAGEN IN MICE [J].

GIRI, SN ;

HYDE, DM ;

HOLLINGER, MA .

THORAX, 1993, 48 (10) :959-966

[3] The myofibroblast - One function, multiple origins [J].

Hinz, Boris ;

Phan, Sem H. ;

Thannickal, Victor J. ;

Galli, Andrea ;

Bochaton-Piallat, Marie-Luce ;

Gabbiani, Giulio .

AMERICAN JOURNAL OF PATHOLOGY, 2007, 170 (06) :1807-1816

[4] The extracellular matrix and transforming growth factor-β1: Tale of a strained relationship [J].

Hinz, Boris .

MATRIX BIOLOGY, 2015, 47 :54-65

[5] Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-β1-induced extracellular matrix expression [J].

Jinnin, M ;

Ihn, H ;

Tamaki, K .

MOLECULAR PHARMACOLOGY, 2006, 69 (02) :597-607

[6] Antifibrotic Effects of Noscapine through Activation of Prostaglandin E2 Receptors and Protein Kinase A [J].

Kach, Jacob ;

Sandbo, Nathan ;

La, Jennifer ;

Denner, Darcy ;

Reed, Eleanor B. ;

Akimova, Olga ;

Koltsova, Svetlana ;

Orlov, Sergei N. ;

Dulin, Nickolai O. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (11) :7505-7513

[7] TGF-β signaling and the fibrotic response [J].

Leask, A ;

Abraham, DJ .

FASEB JOURNAL, 2004, 18 (07) :816-827

[8] Connective tissue growth factor: a new and important player in the pathogenesis of fibrosis. [J].

Leask A. ;

Holmes A. ;

Abraham D.J. .

Current Rheumatology Reports, 2002, 4 (2) :136-142

[9] Adenovector-mediated gene transfer of active transforming growth factor-beta 1 induces prolonged severe fibrosis in rat lung [J].

Sime, PJ ;

Xing, Z ;

Graham, FL ;

Csaky, KG ;

Gauldie, J .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (04) :768-776

[10]

Thannickal Victor J, 2006, Proc Am Thorac Soc, V3, P350, DOI 10.1513/pats.200601-001TK

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