A NEW PREPARATIVE METHOD FOR THE SYNTHESIS OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID

被引：5

作者：

Tribulovich, V. G. ^{[1
]}

Garabadzhiu, A. V. ^{[2
]}

Kalvin'sh, I. ^{[3
]}

机构：

[1] Minist Hlth & Social Dev Russian Federat, Sci Res Inst Influenza, St Petersburg, Russia

[2] St Petersburg State Technol Inst Tech Univ, St Petersburg, Russia

[3] Latvian Acad Sci, Inst Organ Synth, LV-226006 Riga, Latvia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 45卷 / 04期

关键词：

Adapalene; 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid; 3-(1-adamantyl)-4-methoxyphenylboronic acid; synthesis; Suzuki-Miyaura cross-coupling; BR/MG EXCHANGE;

D O I：

10.1007/s11094-011-0605-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new method for the synthesis of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) was developed, characterized by stable high yields of intermediate and end products, simple scale-up, and technical feasibility.

引用

页码：241 / 244

页数：4

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