A NEW PREPARATIVE METHOD FOR THE SYNTHESIS OF 6-[3-(1-ADAMANTYL)-4-METHOXYPHENYL]-2-NAPHTHOIC ACID

被引：5
|
作者：
Tribulovich, V. G. [1 ]
Garabadzhiu, A. V. [2 ]
Kalvin'sh, I. [3 ]
机构：
[1] Minist Hlth & Social Dev Russian Federat, Sci Res Inst Influenza, St Petersburg, Russia
[2] St Petersburg State Technol Inst Tech Univ, St Petersburg, Russia
[3] Latvian Acad Sci, Inst Organ Synth, LV-226006 Riga, Latvia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2011年 / 45卷 / 04期
关键词：
Adapalene; 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid; 3-(1-adamantyl)-4-methoxyphenylboronic acid; synthesis; Suzuki-Miyaura cross-coupling; BR/MG EXCHANGE;
D O I：
10.1007/s11094-011-0605-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new method for the synthesis of 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene) was developed, characterized by stable high yields of intermediate and end products, simple scale-up, and technical feasibility.
引用
收藏
页码：241 / 244
页数：4
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