Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery

被引：23

作者：

Wang, Tingting ^{[1
,2
]}

Zhang, Xuli ^{[1
]}

Pan, Ying ^{[3
]}

Miao, Xiumin ^{[1
]}

Su, Zhongmin ^{[1
]}

Wang, Chungang ^{[1
]}

Li, Xiaomeng ^{[3
]}

机构：

[1] NE Normal Univ, Sch Chem, Changchun 130024, Peoples R China

[2] Changchun Univ Sci & Technol, Sch Chem & Environm Engn, Changchun 130022, Peoples R China

[3] NE Normal Univ, Sch Life Sci, Inst Cytol & Genet, Changchun 130024, Peoples R China

来源：

DALTON TRANSACTIONS | 2011年 / 40卷 / 38期

基金：

中国国家自然科学基金;

关键词：

PHOTOTHERMAL THERAPY; IN-VIVO; BIOMEDICAL APPLICATIONS; CONTRAST AGENTS; NANOPARTICLES; POLYELECTROLYTE; NANOTECHNOLOGY; CELLS;

D O I：

10.1039/c1dt10565e

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel strategy was utilized to develop a stable probe based on thiolated poly(ethylene glycol) (SH-PEG) and polyacrylic acid (PAA) functionalized gold nanorods (GNRs), following the attachment of an anti-cancer drug, doxorubicin (DOX), to obtain PAA-PEG-GNRs@DOX assemblies. Importantly, the obtained probe as a novel drug-delivery and fluorescent imaging agent for simultaneous imaging of and drug delivery to prostate cancer cells has also been demonstrated. In addition to designing PAA-PEG-GNRs that passively target tumor cells for cancer-fighting drug therapy, GNRs are also regarded as hyperthermia agents for photokilling cancer cells, so that the tumor would be attacked on two fronts simultaneously.

引用

页码：9789 / 9794

页数：6

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