Fibrinoid reaction after lens extraction in rabbit eyes

被引:5
作者
Ben Simon, Guy J. [1 ,3 ]
Kenet, Gili [2 ,3 ]
Spierer, Abraham [1 ,3 ]
机构
[1] Chaim Sheba Med Ctr, Goldschleger Eye Inst, IL-52621 Tel Hashomer, Israel
[2] Chaim Sheba Med Ctr, Natl Hemophilia Ctr, IL-52621 Tel Hashomer, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
关键词
BLOOD-AQUEOUS BARRIER; CATARACT-SURGERY; FLUOROPHOTOMETRY; IMPLANTATION; HYDROGEL;
D O I
10.1016/j.jcrs.2011.12.026
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
PURPOSE: To measure the inflammatory reaction in the anterior chamber after lens extraction in a rabbit model and to evaluate the effect of nonsteroidal antiinflammatory drugs (NSAIDs) or steroids on the amount of inflammation as measured by fibrinogen levels in the aqueous humor. SETTING: Animal laboratory, Goldschleger Research Institute, Tel Aviv University, Sheba Medical Center, Ramat Gan, Israel. DESIGN: Experimental study. MATERIALS: Twenty-six eyes of New Zealand white rabbits had lens extraction surgery. One day later, aqueous humor (similar to 0.1 mL) was withdrawn from the anterior chamber and examined for fibrinogen concentration. Control rabbits received no treatment (9 eyes) or artificial tear eyedrops (5 eyes). One study group received NSAID drops (diclofenac) (6 eyes), and another study group received steroid drops (dexamethasone-neomycin) (6 eyes). All rabbits were treated hourly for 9 applications. Aqueous humor (similar to 0.1 mL) was withdrawn from the anterior chamber and examined for fibrinogen concentration 1 day later. Fibrinogen levels were also measured in the aqueous in 8 unoperated eyes. RESULTS: Steroid-treated eyes achieved the lowest inflammatory score, followed by NSAID eyes, artificial tears eyes, and untreated eyes. The mean fibrinogen concentrations in the aqueous humor were 69.1 mg% untreated, 52.0 mg% artificial tears, 18.5 mg% NSAIDs, and 2.8 mg% steroids (P=.002). CONCLUSIONS: Measurement of aqueous fibrinogen after lens extraction surgery in a rabbit animal model was simple and provided a useful parameter for precise evaluation of postoperative intraocular reaction. Steroids and NSAIDs were effective in reducing postoperative inflammation. Steroids reduced inflammation to almost undetectable values.
引用
收藏
页码:890 / 893
页数:4
相关论文
共 12 条
[1]  
Caprioli J., 1992, ADLERS PHYSL EYE CLI, P228
[2]   ASSESSMENT OF THE BLOOD-AQUEOUS BARRIER BY FLUOROPHOTOMETRY FOLLOWING POLY(METHYL METHACRYLATE), SILICONE, AND HYDROGEL LENS IMPLANTATION IN RABBIT EYES [J].
CARLSON, KH ;
CAMERON, JD ;
LINDSTROM, RL .
JOURNAL OF CATARACT AND REFRACTIVE SURGERY, 1993, 19 (01) :9-15
[3]  
CLAUSS A., 1957, ACTA HAEMATOL, V17, P237
[4]  
HIGGINBOTHAM EJ, 1987, ARCH OPHTHALMOL-CHIC, V105, P540
[5]   Disruption of the blood-aqueous barrier following retinal laser photocoagulation and cryopexy in pigmented rabbits [J].
Inoue, M ;
Tsukahara, Y ;
Shirabe, H ;
Yamamoto, M .
OPHTHALMIC RESEARCH, 2001, 33 (01) :37-41
[6]   INHIBITION OF INTRAOCULAR FIBRIN FORMATION FOLLOWING INFUSION OF LOW-MOLECULAR-WEIGHT HEPARIN DURING VITRECTOMY [J].
IVERSON, DA ;
KATSURA, H ;
HARTZER, MK ;
BLUMENKRANZ, MS .
ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (03) :405-409
[7]  
KAYAZAWA F, 1984, ARCH OPHTHALMOL-CHIC, V102, P1169
[8]   FIBRINOGEN CONCENTRATION IN THE AQUEOUS-HUMOR OF BUPHTHALMIC RABBITS [J].
LAM, KW ;
MANSOUR, AM ;
FOX, RR ;
LEE, PF ;
SMITH, R .
CURRENT EYE RESEARCH, 1982, 2 (03) :153-157
[9]   Recombinant hirudin prevents postoperative fibrin formation after experimental cataract surgery [J].
Mittra, RA ;
Dev, S ;
Nasir, MA ;
Toth, CA .
OPHTHALMOLOGY, 1997, 104 (03) :558-561
[10]  
MIYAKE K, 1989, OPHTHALMOLOGY, V96, P1228