Tumor-Targeting Gold Particles for Dual Computed Tomography/Optical Cancer Imaging

被引：102

作者：

Sun, In-Cheol ^{[1
]}

Eun, Dae-Kyung ^{[2
]}

Koo, Heebeom ^{[1
]}

Ko, Chang-Yong ^{[3
]}

Kim, Han-Sung ^{[3
]}

Yi, Dong Kee ^{[4
]}

Choi, Kuiwon ^{[1
]}

Kwon, Ick Chan ^{[1
]}

Kim, Kwangmeyung ^{[1
]}

Ahn, Cheol-Hee ^{[2
]}

机构：

[1] Korea Inst Sci & Technol, Ctr Theragnosis, Biomed Res Inst, Seoul 136791, South Korea

[2] Seoul Natl Univ, Dept Mat Sci & Engn, RIAM, Seoul 151744, South Korea

[3] Yonsei Univ, Dept Biomed Engn, Wonju 220710, Ganwondo, South Korea

[4] Kyungwon Univ, Gachon Bionano Inst, Div Bionanotechnol, Geonggi Do 461701, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 40期

关键词：

computed tomography; gold; imaging agents; nanoparticles; NANOPARTICLES; DELIVERY; ANCHOR;

D O I：

10.1002/anie.201102892

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：9348 / 9351

页数：4

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