NO-Rich Diet for Lifestyle-Related Diseases

被引：65

作者：

Kobayashi, Jun ^{[1
]}

Ohtake, Kazuo ^{[1
]}

Uchida, Hiroyuki ^{[1
]}

机构：

[1] Josai Univ, Div Pathophysiol, Dept Clin Dietet & Human Nutr, Fac Pharmaceut Sci, Saitama 3500295, Japan

来源：

NUTRIENTS | 2015年 / 7卷 / 06期

关键词：

lifestyle-related disease; nitric oxide (NO); nitrate; nitrite; insulin resistance; ischemia; reperfusion injury; chronic obstructive pulmonary disease (COPD); osteoporosis; cancer; NITRIC-OXIDE SYNTHASE; CURED MEAT CONSUMPTION; OBSTRUCTIVE PULMONARY-DISEASE; INSULIN-RECEPTOR SUBSTRATE-1; INDUCED ENDOGENOUS FORMATION; REDUCES BLOOD-PRESSURE; BONE-MINERAL DENSITY; CARDIOVASCULAR-DISEASE; INORGANIC NITRATE; VEGETABLE INTAKE;

D O I：

10.3390/nu7064911

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Decreased nitric oxide (NO) availability due to obesity and endothelial dysfunction might be causally related to the development of lifestyle-related diseases such as insulin resistance, ischemic heart disease, and hypertension. In such situations, instead of impaired NO synthase (NOS)-dependent NO generation, the entero-salivary nitrate-nitrite-NO pathway might serve as a backup system for NO generation by transmitting NO activities in the various molecular forms including NO and protein S-nitrosothiols. Recently accumulated evidence has demonstrated that dietary intake of fruits and vegetables rich in nitrate/nitrite is an inexpensive and easily-practicable way to prevent insulin resistance and vascular endothelial dysfunction by increasing the NO availability; a NO-rich diet may also prevent other lifestyle-related diseases, including osteoporosis, chronic obstructive pulmonary disease (COPD), and cancer. This review provides an overview of our current knowledge of NO generation through the entero-salivary pathway and discusses its safety and preventive effects on lifestyle-related diseases.

引用

页码：4911 / 4937

页数：27

共 166 条

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