Recent Advances in the Field of 16-Membered Macrolide Antibiotics

被引：16
作者：
Cui, W. [1 ]
Ma, S. [1 ]
机构：
[1] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Jinan 250012, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 12期
基金：
中国国家自然科学基金;
关键词：
16-membered macrolides; structural flexibility; mycarose moiety; antimicrobial properties; resistant strains; resistance mechanism; tylosin; leucomycin; 23S RIBOSOMAL-RNA; RESISTANCE MECHANISMS; CONFERRING RESISTANCE; TYLOSIN; ERYTHROMYCIN; DERIVATIVES; MUTATION; GENE; SUSCEPTIBILITY; STREPTOGRAMIN;
D O I：
10.2174/138955711797247734
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The continuing emergence of bacterial resistance has provided an incentive for recent intensified research on macrolide antibiotics. Belonging to the macrolide family, 16-membered macrolides also experience a renewed interest in further exploration. The medicinal potential of 16-membered macrolides in search for new antibacterials stems from some advantages over 14-membered macrolides, such as gastrointestinal tolerability, structural flexibility, and lack of inducible resistance. Thus, compared with abundant articles on various 14-membered macrolide derivatives in the literature, this review will highlight some representative 16-membered macrolide antibiotics and their recently discovered analogs. Furthermore, the action and resistance mechanisms of 16-membered macrolide antibiotics will be elucidated as well to assist the drug design.
引用
收藏
页码：1009 / 1018
页数：10
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