Venous Thromboembolic Events in Adolescent and Young Adult Patients with Acute Lymphoblastic Leukemia

被引：1

作者：

Jones, Sandra R. ^{[1
]}

Patel, Roshni B. ^{[1
]}

Rahim, Mahvish Q. ^{[2
]}

Althouse, Sandra K. ^{[3
]}

Batra, Sandeep ^{[2
,4
]}

机构：

[1] Indiana Univ Sch Med, Dept Pediat, Indianapolis, IN 46202 USA

[2] Riley Hosp Children, Dept Pediat, Indianapolis, IN USA

[3] Indiana Univ, Dept Biostat & Hlth Data Sci, Indianapolis, IN 46204 USA

[4] Melvin & Bren Simon Canc Ctr, Indianapolis, IN USA

来源：

JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY | 2022年 / 11卷 / 06期

关键词：

venous thromboembolism; obesity; hypoalbuminemia; acute lymphoblastic leukemia; THROMBOSIS; RISK; BILIRUBIN; CHILDREN;

D O I：

10.1089/jayao.2021.0136

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute venous thromboembolisms (VTEs) are serious complications that occur during acute lymphoblastic leukemia (ALL) chemotherapy. The data elucidating risk factors for developing VTEs are limited in adolescent and young adult patients being treated per pediatric ALL protocols. In a cohort of 66 patients, 14 (21%) experienced VTEs. The majority of VTEs occurred during induction chemotherapy after the first dose of asparaginase, and in the upper extremities. Five-year relapse-free and overall survival were not impacted by VTEs. Contrary to VTEs in adults, hypoalbuminemia and increased body mass index were not associated with an elevated risk of VTE.

引用

页码：600 / 604

页数：5

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