N-Heterocyclic carbene-catalyzed diastereoselective synthesis of β-lactone-fused cyclopentanes using homoenolate annulation reaction

被引：24

作者：

Mukherjee, Subrata ^{[1
]}

Mondal, Santigopal ^{[1
]}

Patra, Atanu ^{[1
]}

Gonnade, Rajesh G. ^{[2
]}

Biju, Akkattu T. ^{[1
]}

机构：

[1] CSIR Natl Chem Lab CSIR NCL, Div Organ Chem, Pune 411008, Maharashtra, India

[2] CSIR Natl Chem Lab CSIR NCL, Ctr Mat Characterizat, Pune 411008, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 46期

关键词：

STEREOSELECTIVE-SYNTHESIS; FUNCTIONALIZED CYCLOPENTENES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; EFFICIENT SYNTHESIS; KINETIC RESOLUTION; MICHAEL ADDITION; ENALS; ACYL; CHALCONES;

D O I：

10.1039/c5cc02960k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

NHC-catalyzed annulation of enals with 2-enoylpyridines or 2-enoylpyridine N-oxides leading to the diastereoselective synthesis of beta-lactone-fused cyclopentanes is reported. The reaction proceeds via the generation of homoenolate equivalent intermediates and tolerates a broad range of functional groups.

引用

页码：9559 / 9562

页数：4

共 62 条

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