Identification of metabolites of AHTN in rat urine and feces by liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry

被引：3

作者：

Yang, Yi ^{[1
,3
]}

Zhang, Yin ^{[1
,2
]}

Zhang, Jing ^{[1
]}

Shao, Bing ^{[1
,2
]}

机构：

[1] Beijing Ctr Dis Control & Prevent, Beijing Key Lab Diagnost & Traceabil Technol Food, Beijing 100013, Peoples R China

[2] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Peoples R China

[3] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

来源：

ANALYTICAL METHODS | 2015年 / 7卷 / 11期

基金：

中国国家自然科学基金;

关键词：

SYNTHETIC MUSK FRAGRANCES; POLYCYCLIC MUSKS; PERSONAL CARE; SEWAGE-SLUDGE; WASTE-WATER; PRODUCTS; TISSUE; HHCB; AIR;

D O I：

10.1039/c4ay03063j

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

6-Acetyl-1,1,2,4,4,7-hexamethyltetraline (AHTN) is widely used polycyclic musk with raised environmental and health concerns during the last decade, but the metabolites of AHTN in model animals such as rats are unknown. In this study, the major metabolites of AHTN in rat urine and feces were identified by ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-flight tandem mass spectrometry (UPLC/ESI-QTOF-MS). Three hydroxylation metabolites and three carboxyl metabolites were found in urine and feces.

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收藏

页码：4443 / 4449

页数：7

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