Developments in the Antitumor Activity, Mechanisms of Action, Structural Modifications, and Structure-Activity Relationships of Steroidal Saponins

被引：5

作者：

An, Renfeng ^{[1
]}

Zhang, Wenjin ^{[1
]}

Huang, Xuefeng ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2022年 / 22卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Steroidal saponin; steroidal sapogenin; antitumor activity; mechanisms of action; structural modification; structure-activity relationships; CELL-CYCLE ARREST; BETA-D-GLUCOPYRANOSIDE; LUNG-CANCER CELLS; BIOLOGICAL EVALUATION; SARSASAPOGENIN DERIVATIVES; MITOCHONDRIAL DYSFUNCTION; DIOSCIN DERIVATIVES; ANTICANCER ACTIVITY; SPIROSTAN SAPONINS; CYTOTOXIC ACTIVITY;

D O I：

10.2174/1389557522666220217113719

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Steroidal saponins, a class of natural products formed by the combination of spirosteranes with sugars, are widely distributed in plants and have various biological activities, such as anti-tumor, anti-inflammatory, anti-bacterial, anti-Alzheimer's, anti-oxidation, etc. Particularly, extensive research on the antitumor property of steroidal saponins has been conducted. Steroidal sapogenins, the aglycones of steroidal saponins, also have attracted much attention due to a vast range of pharmacological activities similar to steroidal saponins. In the past few years, structural modifications on the aglycones and sugar chains of steroidal saponins have been carried out and some achievements have been made. In this mini-review, the antitumor activity, action mechanisms, and structural modifications, along with the structure-activity relationships of steroidal saponins and their derivatives, are summarized.

引用

页码：2188 / 2212

页数：25

共 109 条

[1] Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury [J].

Azzam, Edouard I. ;

Jay-Gerin, Jean-Paul ;

Pain, Debkumar .

CANCER LETTERS, 2012, 327 (1-2) :48-60

[2] Biological transformations of steroidal compounds: A review [J].

Bhatti, Haq Nawaz ;

Khera, Rasheed Ahmad .

STEROIDS, 2012, 77 (12) :1267-1290

[3] Paris saponin H inhibits the proliferation of glioma cells through the A1 and A3 adenosine receptor-mediated pathway [J].

Bi, Linlin ;

Liu, Yang ;

Yang, Qian ;

Zhou, Xuanxuan ;

Li, Hua ;

Li, Jie ;

Lu, Yunyang ;

Tang, Haielng .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021, 47 (04)

[4] Design, synthesis of methotrexate-diosgenin conjugates and biological evaluation of their effect on methotrexate transport-resistant cells [J].

Cai, Bangrong ;

Liao, Aimei ;

Lee, Kyung-Ku ;

Ban, Jae-Sam ;

Yang, Hyun-Sam ;

Im, Young Jun ;

Chun, ChangJu .

STEROIDS, 2016, 116 :45-51

[5] Design, Synthesis and Biological Evaluation of Diosgenin-Amino Acid Derivatives with Dual Functions of Neuroprotection and Angiogenesis [J].

Cai, Desheng ;

Qi, Jinchai ;

Yang, Yuqin ;

Zhang, Wenxi ;

Zhou, Fei ;

Jia, Xiaohui ;

Guo, Wenbo ;

Huang, Xuemei ;

Gao, Feng ;

Chen, Hongshan ;

Li, Tong ;

Li, Guoping ;

Wang, Penglong ;

Zhang, Yuzhong ;

Lei, Haimin .

MOLECULES, 2019, 24 (22)

[6] A Perspective on Cancer Cell Metastasis [J].

Chaffer, Christine L. ;

Weinberg, Robert A. .

SCIENCE, 2011, 331 (6024) :1559-1564

[7] Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo [J].

Chang, Junli ;

Li, Yimian ;

Wang, Xianyang ;

Hu, Shaopu ;

Wang, Hongshen ;

Shi, Qi ;

Wang, Yongjun ;

Yang, Yanping .

SCIENTIFIC REPORTS, 2017, 7

[8] Molecular mechanisms of Polyphyllin I-induced apoptosis and reversal of the epithelial-mesenchymal transition in human osteosarcoma cells [J].

Chang, Junli ;

Wang, Hongshen ;

Wang, Xianyang ;

Zhao, Yongjian ;

Zhao, Dongfeng ;

Wang, Chenglong ;

Li, Yimian ;

Yang, Zhilie ;

Lu, Sheng ;

Zeng, Qinghua ;

Zimmerman, Jacquelyn ;

Shi, Qi ;

Wang, Yongjun ;

Yang, Yanping .

JOURNAL OF ETHNOPHARMACOLOGY, 2015, 170 :117-127

[9] Ophiopogonin B suppresses the metastasis and angiogenesis of A549 cells in vitro and in vivo by inhibiting the EphA2/Akt signaling pathway [J].

Chen, Meijuan ;

Hu, Cheng ;

Guo, Yuanyuan ;

Jiang, Rilei ;

Jiang, Huimin ;

Zhou, Yu ;

Fu, Haian ;

Wu, Mianhua ;

Zhang, Xu .

ONCOLOGY REPORTS, 2018, 40 (03) :1339-1347

[10] Diosgenin, a Steroidal Saponin, Inhibits Migration and Invasion of Human Prostate Cancer PC-3 Cells by Reducing Matrix Metalloproteinases Expression [J].

Chen, Shern ;

Shih, Yuan-Wei ;

Huang, Hsiang-Ching ;

Cheng, Hsing-Wen .

PLOS ONE, 2011, 6 (05)

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