IVAC MUTANOME: A first-in-human phase I clinical trial targeting individual mutant neoantigens for the treatment of melanoma

被引：0

作者：

Miller, M. ^{[1
]}

Sahin, U. ^{[2
]}

Derhovanessian, E. ^{[3
]}

Kloke, B-P. ^{[1
]}

Simon, P. ^{[4
]}

Bukur, V. ^{[5
]}

Albrecht, C. ^{[6
]}

Paruzynski, A. ^{[5
]}

Loewer, M. ^{[7
]}

Kuhn, A. ^{[8
]}

Schreeb, K. ^{[9
]}

Attig, S. ^{[10
]}

Brueck, A. Kemmer ^{[9
]}

Bolte, S. ^{[9
]}

Grabbe, S. ^{[11
]}

Hoeller, C. ^{[12
]}

Utikal, J. ^{[13
]}

Huber, C. ^{[14
]}

Loquai, C. ^{[11
]}

Tuereci, O. ^{[15
]}

机构：

[1] Biopharmaceut New Technol BioNTech Corp, Project Management, Mainz, Germany

[2] Biopharmaceut New Technol BioNTech Corp, Management, Mainz, Germany

[3] Biopharmaceut New Technol BioNTech Corp, Immunomonitoring, Mainz, Germany

[4] Biopharmaceut New Technol BioNTech Corp, Immunoreceptor Validat, Mainz, Germany

[5] Biopharmaceut New Technol BioNTech Corp, Genom, Mainz, Germany

[6] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Genom, Mainz, Germany

[7] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Bioinformat, Mainz, Germany

[8] Biopharmaceut New Technol BioNTech Corp, RNA Biochem, Mainz, Germany

[9] Biopharmaceut New Technol BioNTech Corp, Clin Res, Mainz, Germany

[10] Johannes Gutenberg Univ gGmbH, Univ Med Ctr, TRON Translat Oncol, Immunmonitoring, Mainz, Germany

[11] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dermatol, Mainz, Germany

[12] Med Univ Vienna, Dermatol, Vienna, Austria

[13] German Canc Res Ctr, Dermatol, Heidelberg, Germany

[14] Biopharmaceut New Technol BioNTech Corp, Advisory Board, Mainz, Germany

[15] CI3 Cluster Individualized Immunointervent, Management, Mainz, Germany

来源：

ANNALS OF ONCOLOGY | 2017年 / 28卷

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页数：2

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[31] First-in-human phase I clinical trial of a recombinant vesicular stomatitis virus (rVSV)-based preventive HIV-1 vaccine [J].

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