Nodular Vascular Transformation of the Lymph Node Sinuses Mimicking Sarcomatoid Change in Renal Cell Carcinoma: A Potential Diagnostic Pitfall

被引：1
作者：
Mignano, Salvatore E. [1 ]
Russell, Daniel H. [1 ]
机构：
[1] Tripler Army Med Ctr, Honolulu, HI 96859 USA
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2020年 / 28卷 / 06期
关键词：
vascular transformation of lymph node sinuses; sarcomatoid renal cell carcinoma; high-grade renal cell carcinoma; clear cell renal cell carcinoma; metastatic renal cell carcinoma; vascular proliferations; sarcomatoid differentiation; KAPOSIS-SARCOMA; TUMORS; MARKER;
D O I：
10.1177/1066896920916243
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Vascular transformation of the lymph node sinuses (VTS) is an uncommon phenomenon that is believed to occur secondary to obstruction of efferent lymphatics, frequently occuring in retroperitoneal lymph nodes draining cancer. The nodular subtype of VTS, in particular, can mimic metastatic cancer, such as metastatic renal cell carcinoma with sarcomatoid differentiation, potentially resulting in inaccurate tumor grading and/or staging. We present a case of nodular VTS mimicking metastatic renal cell carcinoma with sarcomatoid differentiation in a patient with high-grade clear cell renal cell carcinoma, and explore the relevant differential diagnosis. Awareness of VTS is essential to avoid misdiagnosis of this benign and curative condition.
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页码：637 / 642
页数：6
相关论文
共 28 条
[1]   EMT: 2016 [J].
Angela Nieto, M. ;
Huang, Ruby Yun-Ju ;
Jackson, Rebecca A. ;
Thiery, Jean Paul .
CELL, 2016, 166 (01) :21-45
[2]   Immunohistochemical Analysis of Endothelial Cells in Vascular Transformation of Lymph Node Sinuses: Vascular or Lymphatic Differentiation? [J].
Basha, Basma M. ;
Hsi, Eric D. .
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY, 2019, 27 (06) :482-489
[3]   Radical Nephrectomy with and without Lymph-Node Dissection: Final Results of European Organization for Research and Treatment of Cancer (EORTC) Randomized Phase 3 Trial 30881 [J].
Blom, Jan H. M. ;
van Poppel, Hein ;
Marechal, Jean M. ;
Jacqmin, Didier ;
Schroder, Fritz H. ;
de Prijck, Linda ;
Sylvester, Richard .
EUROPEAN UROLOGY, 2009, 55 (01) :28-34
[4]   Evaluation of Immunohistochemistry in Identifying Bartonella henselae in Cat-Scratch Disease [J].
Caponetti, Gabriel C. ;
Pantanowitz, Liron ;
Marconi, Sharon ;
Havens, Jennifer M. ;
Lamps, Laura W. ;
Otis, Christopher N. .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2009, 131 (02) :250-256
[5]   PRIMARY VASCULAR TUMORS OF LYMPH-NODES OTHER THAN KAPOSIS-SARCOMA - ANALYSIS OF 39 CASES AND DELINEATION OF 2 NEW ENTITIES [J].
CHAN, JKC ;
FRIZZERA, G ;
FLETCHER, CDM ;
ROSAI, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1992, 16 (04) :335-350
[6]   Sarcomatoid renal cell carcinoma - An examination of underlying histologic subtype and an analysis of associations with patient outcome [J].
Cheville, JC ;
Lohse, CM ;
Zincke, H ;
Weaver, AL ;
Leibovich, BC ;
Frank, I ;
Blute, ML .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2004, 28 (04) :435-441
[7]   Sarcomatoid renal cell carcinoma is an example of epithelial-mesenchymal transition [J].
Conant, Joanna L. ;
Peng, Zhihua ;
Evans, Mark F. ;
Naud, Shelly ;
Cooper, Kumarasen .
JOURNAL OF CLINICAL PATHOLOGY, 2011, 64 (12) :1088-1092
[8]   NODULAR SPINDLE-CELL VASCULAR TRANSFORMATION OF LYMPH-NODES - A BENIGN PROCESS OCCURRING PREDOMINANTLY IN RETROPERITONEAL LYMPH-NODES DRAINING CARCINOMAS THAT CAN SIMULATE KAPOSIS-SARCOMA OR METASTATIC TUMOR [J].
COOK, PD ;
CZERNIAK, B ;
CHAN, JKC ;
MACKAY, B ;
ORDONEZ, NG ;
AYALA, AG ;
ROSAI, J .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (09) :1010-1020
[9]   Sarcomatoid differentiation in renal cell carcinoma - A study of 101 cases [J].
de Peralta-Venturina, M ;
Moch, H ;
Amin, M ;
Tamboli, P ;
Hailemariam, S ;
Mihatsch, M ;
Javidan, J ;
Stricker, H ;
Ro, JY ;
Amin, MB .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2001, 25 (03) :275-284
[10]  
Delahunt B, 2013, AM J SURG PATHOL, V37, P1490, DOI 10.1097/PAS.0b013e318299f0fb
123