Amplifying RNA Vaccine Development

被引：93

作者：

Fuller, Deborah H. ^{[1
]}

Berglund, Peter ^{[2
]}

机构：

[1] Univ Washington, Sch Med, Dept Microbiol, Seattle, WA 98195 USA

[2] HDT Bio, Seattle, WA USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2020年 / 382卷 / 25期

关键词：

IMMUNE-RESPONSES;

D O I：

10.1056/NEJMcibr2009737

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are several strategies to elicit immunity with an RNA vaccine; they all involve coaxing the host cell to replicate and translate an exogenous RNA encoding the vaccine antigen. A recent study describes a new, versatile approach.

引用

页码：2469 / 2471

页数：3

共 5 条

[1] A Trans-amplifying RNA Vaccine Strategy for Induction of Potent Protective Immunity
Beissert, Tim
Perkovic, Mario
Vogel, Annette
Erbar, Stephanie
Walzer, Kerstin C.
Hempel, Tina
Brill, Silke
Haefner, Erik
Becker, Rene
Tureci, Ozlem
Sahin, Ugur
[J]. MOLECULAR THERAPY, 2020, 28 (01) : 119 - 128
[2] Enhancing immune responses using suicidal DNA vaccines
Berglund, P
Smerdou, C
Fleeton, MN
Tubulekas, I
Liljeström, P
[J]. NATURE BIOTECHNOLOGY, 1998, 16 (06) : 562 - 565
[3] Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses
Vogel, Annette B.
Lambert, Laura
Kinnear, Ekaterina
Busse, David
Erbar, Stephanie
Reuter, Kerstin C.
Wicke, Lena
Perkovic, Mario
Beissert, Tim
Haas, Heinrich
Reece, Stephen T.
Sahin, Ugur
Tregoning, John S.
[J]. MOLECULAR THERAPY, 2018, 26 (02) : 446 - 455
[4] DIRECT GENE-TRANSFER INTO MOUSE MUSCLE INVIVO
WOLFF, JA
MALONE, RW
WILLIAMS, P
CHONG, W
ACSADI, G
JANI, A
FELGNER, PL
[J]. SCIENCE, 1990, 247 (4949) : 1465 - 1468
[5] GENERATION OF CYTOTOXIC AND HUMORAL IMMUNE-RESPONSES BY NONREPLICATIVE RECOMBINANT SEMLIKI-FOREST-VIRUS
ZHOU, XZ
BERGLUND, P
ZHAO, HX
LILJESTROM, P
JONDAL, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) : 3009 - 3013

← 1 →