The Burden of Pain Associated with Osteoarthritis in the Hip or Knee from the Patient's Perspective: A Multinational Cross-Sectional Study

被引:44
作者
Jackson, James [1 ]
Iyer, Ravi [2 ]
Mellor, Jennifer [1 ]
Wei, Wenhui [3 ]
机构
[1] Adelphi Real World, Bollington, England
[2] Teva Pharmaceut Ind Ltd, Global Hlth Econ & Outcomes Res, Frazer, PA USA
[3] Regeneron Pharmaceut Inc, Hlth Econ & Outcomes Res, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA
关键词
Comorbidity; Daily activity; Health-related quality of life; Opioid; Osteoarthritis; Pain; Physical functioning; Work productivity; QUALITY-OF-LIFE; STANDING-COMMITTEE; HEALTH-STATUS; TASK-FORCE; MANAGEMENT; IMPACT; RECOMMENDATIONS; COMORBIDITY; INSTRUMENT; OPIOIDS;
D O I
10.1007/s12325-020-01445-4
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Introduction To evaluate, from the patient's perspective, the burden of pain associated with hip/knee osteoarthritis (OA) in the USA and selected European Union (EU) countries. Methods Data were drawn from the 2017 global Adelphi OA Disease Specific Programme (TM) (DSP). Patients with hip/knee OA were stratified based on pain intensity and the presence/absence of current opioid use. Outcomes included Western Ontario and McMaster Universities Osteoarthritis Index scores, functional limitations, unmet treatment needs, Charlson Comorbidity Index, relevant comorbid conditions, the 5-dimension 5-level EuroQol, and the Work Productivity and Activity Impairment Questionnaire: Specific Health Problem. Bivariate testing compared outcomes using patients with no/mild pain without opioid use as the reference group. Results The study population comprised 2170 patients (US:n = 623 [28.7%]; EU:n = 1547 [71.3%]) with knee (54.9%), hip (24.6%), or knee/hip (20.5%) OA. Mean (SD) age was 66.4 (11.2) years. Patients had no/mild pain without opioid use (39.6%), no/mild pain with opioid use (10.2%), moderate/severe pain without opioid use (30.6%), and moderate/severe pain with opioid use (19.7%). Compared with the reference group, patients with moderate/severe pain reported significantly (p < 0.05) higher functional limitations, greater use of >= 3 treatments and treatment dissatisfaction, reduced quality of life, and impaired work productivity and activity. The burden was highest with moderate/severe pain with opioid use. Results were generally similar in the US and EU cohorts. Conclusions The results from this multinational cross-sectional study indicate that the impact of OA pain is multidimensional, worsened by increasing pain intensity, and may not be adequately addressed by current treatment strategies.
引用
收藏
页码:3985 / 3999
页数:15
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