Uric acid and blood pressure in NHANES dated from 2009 to 2018: A cross-sectional research

Background and aim: This study aimed to explore the association between uric acid (UA) and blood pressure (BP), included systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial pressure (MAP).Methods and results: A cross-sectional study with 22,478 individuals aged from 12 to 80 years (11,443 males and 11,035 females) from the National Health and Nutrition Examination Survey (NHANES) was performed. Multiple linear regression analysis was applied to explore the rela-tionship between UA and BP, Stratified analysis and interaction were performed based on gender, race, age, body mass index (BMI), and alcohol consumption. Significantly positively associations were presented in SBP(0, 0.84 [95% CI, 0.67, 1.00]), DBP(0, 0.23 [95% CI, 0.11, 0.36]), and MAP (0, 0.43 [95% CI, 0.31, 0.55]). The associations were much more stronger between UA and SBP in fe-males (0, 1.04 [95% CI, 0.78, 1.30], p for interaction 0.0003), black group (0, 1.17 [95% CI, 0.77, 1.56], p for interaction 0.0296), age (>= 45) group (0, 1.03 [95% CI, 0.68, 1.39], p for interaction <0.0001) and drinking group (0, 0.98 [95% CI, 0.75, 1.21], p for interaction <0.0001). The significant inter-actions were found between UA and DBP in gender and alcohol consumption (all p for interac-tion <0.05). In terms of MAP, the significant interactions were found in race, age, and alcohol consumption (all p for interaction <0.05).Conclusions: A significantly positively association was found between UA and BP, including SBP, DBP, and MAP.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.