The clinical and biologic significance of serum inhibins in subfertile men

被引:35
作者
Mahmoud, AM
Comhaire, FH
Depuydt, CE
机构
[1] State Univ Ghent Hosp, Dept Internal Med, Endocrinol Sect, B-9000 Ghent, Belgium
[2] Assiut Univ Hosp, Dept Dermatol & Androl, Assiut, Egypt
关键词
inhibin; male infertility; FSH; sperm concentration; spermatogenesis; human; Sertoli cell; oestrogen;
D O I
10.1016/S0890-6238(98)00042-2
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Inhibin B is a marker of spermatogenesis and Sertoli cell function. The objective of this study was to evaluate the biologic significance of inhibins in subfertile men and the usefulness of inhibin B for the detection of male reproductive dysfunction, Forty-seven subfertile men were evaluated by semen analysis and clinical examination. In addition to semen analysis and hormone determinations, inhibins A and B (Serotec) in all 47 and inhibin A in 25 of these samples using another kit (Biosource) were measured. Higher inhibin B (median, range: 160.3, 81.8-328.5 pg/mL vs, 94.9, 15.6-389.7 pg/mL, P = 0.024) and lower FSH (P = 0.001) were detected in men with sperm concentrations greater than or equal to 20 million/mL (n = 9), compared to oligozoospermia (sperm concentration <20 million/mL, n = 38), Inhibin B correlated significantly negatively with FSH, LH, and E-2, and patient's age and positively with sperm concentration, testicular volume, and TSH, Multiple regression analysis indicated FSH, LH, E-2, TSH, and age as the independent variables for inhibin B with a coefficient of determination (R) of 0.53, Simultaneous measurement of both FSH and inhibin B identified more cases with oligozoospermia than either hormone alone. Taking into account the body mass index, the age of the patient, and the indirect mixed antiglobin reaction (MAR) test result in addition to FSH and inhibin B led to the correct semen classification in 45 out of 47 cases. The simultaneous measurement of FSH and inhibin B, taking into account age, body mass index, and the indirect MAR test result appears accurate in identifying subfertility. Inhibin A is detectable in some subfertile men but its significance is not clear. (C) 1998 Elsevier Science Inc.
引用
收藏
页码:591 / 599
页数:9
相关论文
共 38 条
[1]   EVIDENCE THAT SECRETION OF IMMUNOACTIVE INHIBIN BY SEMINIFEROUS TUBULES FROM THE ADULT-RAT TESTIS IS REGULATED BY SPECIFIC GERM-CELL TYPES - CORRELATION BETWEEN INVIVO AND INVITRO STUDIES [J].
ALLENBY, G ;
FOSTER, PMD ;
SHARPE, RM .
ENDOCRINOLOGY, 1991, 128 (01) :467-476
[2]  
Altman DG, 1990, PRACTICAL STAT MED R
[3]   Serum inhibin B levels reflect sertoli cell function in normal men and men with testicular dysfunction [J].
Anawalt, BD ;
Bebb, RA ;
Matsumoto, AM ;
Groome, NP ;
Illingworth, PJ ;
McNeilly, AS ;
Bremner, WJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (09) :3341-3345
[4]   Physiological relationships between inhibin B, follicle stimulating hormone secretion and spermatogenesis in normal men and response to gonadotrophin suppression by exogenous testosterone [J].
Anderson, RA ;
Wallace, EM ;
Groome, NP ;
Bellis, AJ ;
Wu, FCW .
HUMAN REPRODUCTION, 1997, 12 (04) :746-751
[5]   COMPARISON OF DIFFERENT METHODS FOR THE INVESTIGATION OF ANTISPERM ANTIBODIES ON SPERMATOZOA, IN SEMINAL PLASMA AND IN SERUM [J].
ANDREOU, E ;
MAHMOUD, A ;
VERMEULEN, L ;
SCHOONJANS, F ;
COMHAIRE, F .
HUMAN REPRODUCTION, 1995, 10 (01) :125-131
[6]  
ANDRSSON AM, 1997, J CLIN ENDOCR METAB, V82, P3976
[7]  
[Anonymous], 1993, WHO MANUAL STANDARDI
[8]   Editorial: Inhibin in the male - Progress at last [J].
Burger, HG ;
Robertson, DM .
ENDOCRINOLOGY, 1997, 138 (04) :1361-1362
[9]  
COMHAIRE F, 1989, J ANDROL, V1, P50
[10]   TRIIODOTHYRONINE INHIBITS PROLIFERATION AND STIMULATES DIFFERENTIATION OF CULTURED NEONATAL SERTOLI CELLS - POSSIBLE MECHANISM FOR INCREASED ADULT TESTIS WEIGHT AND SPERM PRODUCTION INDUCED BY NEONATAL GOITROGEN TREATMENT [J].
COOKE, PS ;
ZHAO, YD ;
BUNICK, D .
BIOLOGY OF REPRODUCTION, 1994, 51 (05) :1000-1005