Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis

被引：1070

作者：

Bjornevik, Kjetil ^{[1
]}

Cortese, Marianna ^{[1
]}

Healy, Brian C. ^{[2
,3
,4
]}

Kuhle, Jens ^{[5
,6
]}

Mina, Michael J. ^{[7
,8
,9
,10
,11
]}

Leng, Yumei ^{[7
,8
]}

Elledge, Stephen J. ^{[7
,8
]}

Niebuhr, David W. ^{[12
]}

Scher, Ann, I ^{[12
]}

Munger, Kassandra L. ^{[1
]}

Ascherio, Alberto ^{[1
,13
,14
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Partners Multiple Sclerosis Ctr, 75 Francis St, Boston, MA 02115 USA

[3] Harvard Med Sch, Dept Neurol, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Biostat Ctr, Boston, MA USA

[5] Univ Basel, Univ Hosp Basel, Neurol Clin & Policlin, MS Ctr, Basel, Switzerland

[6] Univ Basel, Univ Hosp Basel, Res Ctr Clin Neuroimmunol & Neurosci Basel RC2NB, Basel, Switzerland

[7] Harvard Med Sch, Brigham & Womens Hosp, Howard Hughes Med Inst, Div Genet,Dept Genet, Boston, MA 02115 USA

[8] Harvard Med Sch, Program Virol, Boston, MA 02115 USA

[9] Harvard TH Chan Sch Publ Hlth, Ctr Communicable Dis Dynam, Dept Epidemiol, Boston, MA USA

[10] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA USA

[11] Harvard Med Sch, Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[12] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biostat, Bethesda, MD 20814 USA

[13] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[14] Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA

来源：

SCIENCE | 2022年 / 375卷 / 6578期

基金：

美国国家卫生研究院;

关键词：

NEUROFILAMENT LIGHT; RISK-FACTORS; INFECTION; UNIVERSITY; RESPONSES; BRAIN; CHAIN;

D O I：

10.1126/science.abj8222

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system of unknown etiology. We tested the hypothesis that MS is caused by Epstein-Barr virus (EBV) in a cohort comprising more than 10 million young adults on active duty in the US military, 955 of whom were diagnosed with MS during their period of service. Risk of MS increased 32-fold after infection with EBV but was not increased after infection with other viruses, including the similarly transmitted cytomegalovirus. Serum levels of neurofilament light chain, a biomarker of neuroaxonal degeneration, increased only after EBV seroconversion. These findings cannot be explained by any known risk factor for MS and suggest EBV as the leading cause of MS.

引用

页码：296 / +

页数：27

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