Post-exercise changes in myostatin and actRIIB expression in obese insulin-resistant rats

被引：10
作者：
Bueno, P. G. [2 ]
Bassi, D. [3 ]
Contrera, D. G. [1 ]
Carnielli, H. M. [1 ]
Silva, R. N. [3 ]
Nonaka, K. O. [2 ]
Selistre-de-Araujo, H. S. [2 ]
Leal, A. M. O. [1 ]
机构：
[1] Univ Fed Sao Carlos, Dept Med, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Fed Sao Carlos, Dept Physiol, BR-13565905 Sao Carlos, SP, Brazil
[3] Univ Fed Sao Carlos, Dept Physiotherapy, BR-13565905 Sao Carlos, SP, Brazil
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2011年 / 339卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
Myostatin; Obesity; Exercise; ACTIVATED PROTEIN-KINASE; DIET-INDUCED OBESITY; SKELETAL-MUSCLE; GENE-EXPRESSION; ADIPOSE-TISSUE; WISTAR RATS; WEIGHT-LOSS; NULL MICE; FAT; EXERCISE;
D O I：
10.1016/j.mce.2011.04.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We evaluated the expression of MSTN and ActRIIB mRNA in muscle and adipose tissue in diet-induced obesity and insulin resistance in rats subjected to exercise. There was no difference in the expression of MSTN between exercised and sedentary high-fat fed rats in muscle after swimming training. The expression of ActRIIB mRNA in muscle was not significantly different among the groups. In BAT, MSTN mRNA expression was higher in exercised high-fat fed group (EHF) compared with sedentary high-fat fed group (SHF). ActRIIB mRNA expression in BAT was higher in EHF compared with SHF. In mesenteric fat, MSTN mRNA was lower in EHF compared with SHF and ActRIIB mRNA was lower in EHF compared with SHF. In conclusion, the results demonstrate that the expression of MSTN and ActRIIB mRNA changes in both adipose tissue and skeletal muscle in diet-induced obese and exercised rats and suggest the participation of MSTN in energy homeostasis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：159 / 164
页数：6
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