Inhibition effect of phenyl compounds from the Oryza sativa roots on melanin production in murine B16-F10 melanoma cells

被引：13

作者：

Cho, Jin-Gyeong ^{[1
]}

Huh, Jeongran ^{[2
]}

Jeong, Rak-Hun ^{[1
]}

Cha, Byeong-Ju ^{[1
]}

Shrestha, Sabina ^{[1
]}

Lee, Dong-Geol ^{[2
]}

Kang, Hee-Cheol ^{[2
]}

Kim, Ji-Young ^{[1
]}

Baek, Nam-In ^{[1
]}

机构：

[1] Kyung Hee Univ, Dept Oriental Med Biotechnol, Grad Sch Biotechnol, Yongin 446701, South Korea

[2] GFC Co Ltd, R&D Ctr, Suwon 443813, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2015年 / 29卷 / 11期

关键词：

phenyl compound; anti-melanogenic effect; N-(trans-cinnamoyl)tryptamine; rice root; trans-p-coumaric acid methyl ester; ACID;

D O I：

10.1080/14786419.2014.968155

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Five phenyl compounds, vanillin (1), methyl trans-ferulate (2), trans-p-coumaric acid methyl ester (3), N-benzoyltryptamine (4), and N-(trans-cinnamoyl)tryptamine (5), were isolated from the roots of Oryza sativa L. and identified on the basis of spectroscopic data. Compounds 3 and 5 showed strong inhibition effect on melanin production in murine B16-F10 melanoma cells and tyrosinase activity. Also, the quantitative analysis of the compounds was carried out using LC/MS/MS experiment. Compounds 3 and 5 could be used as skin-whitening agents.

引用

页码：1052 / 1054

页数：3

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