Alcohol use and dementia: a systematic scoping review

被引:196
|
作者
Rehm, Juergen [1 ,2 ,3 ,4 ,5 ,6 ]
Hasan, Omer S. M. [1 ,2 ]
Black, Sandra E. [4 ,7 ,8 ,9 ]
Shield, Kevin D. [1 ,2 ,7 ,8 ]
Schwarzinger, Michael [10 ]
机构
[1] CAMH, Inst Mental Hlth Policy Res, 33 Russell St, Toronto, ON M5S 2S1, Canada
[2] Univ Toronto, Dalla Lana Sch Publ Hlth, 27 Kings Coll Circle, Toronto, ON M5S 1A1, Canada
[3] CAMH, Campbell Family Mental Hlth Res Inst, 250 Coll St, Toronto, ON M5T 1R8, Canada
[4] Univ Toronto, Inst Med Sci, Med Sci Bldg,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada
[5] Univ Toronto, Dept Psychiat, 250 Coll St, Toronto, ON M5T 1R8, Canada
[6] Tech Univ Dresden, Inst Clin Psychol & Psychotherapy, Chemnitzer Str 46, D-01187 Dresden, Germany
[7] Sunnybrook Hlth Sci Ctr, Dept Med Neurol, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
[8] Univ Toronto, 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
[9] Sunnybrook Res Inst, Hurvitz Brain Sci Res Program, Toronto, ON M4N 3M5, Canada
[10] THEN, 39 Quai Valmy, F-75010 Paris, France
关键词
Dementia; Alcohol; Risk; Systematic review; Alzheimer's disease; Vascular dementia; Brain function; Brain volumetrics; Cognition; RISK-FACTORS; ALZHEIMERS-DISEASE; COGNITIVE DECLINE; APOLIPOPROTEIN-E; USE DISORDERS; CONSUMPTION; BRAIN; MORTALITY; DRINKING; METAANALYSIS;
D O I
10.1186/s13195-018-0453-0
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
BackgroundAlcohol use has been identified as a risk factor for dementia and cognitive decline. However, some patterns of drinking have been associated with beneficial effects.Methods and ResultsTo clarify the relationship between alcohol use and dementia, we conducted a scoping review based on a systematic search of systematic reviews published from January 2000 to October 2017 by using Medline, Embase, and PsycINFO. Overall, 28 systematic reviews were identified: 20 on the associations between the level of alcohol use and the incidence of cognitive impairment/dementia, six on the associations between dimensions of alcohol use and specific brain functions, and two on induced dementias. Although causality could not be established, light to moderate alcohol use in middle to late adulthood was associated with a decreased risk of cognitive impairment and dementia. Heavy alcohol use was associated with changes in brain structures, cognitive impairments, and an increased risk of all types of dementia.ConclusionReducing heavy alcohol use may be an effective dementia prevention strategy.
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页数:11
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