Pan-cancer survey of epithelial-mesenchymal transition markers across the Cancer Genome Atlas

被引：88

作者：

Gibbons, Don L. ^{[1
,2
]}

Creighton, Chad J. ^{[3
,4
,5
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Thorac Head & Neck Med Oncol, Houston, TX 77030 USA

[2] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Div Biostat, Houston, TX 77030 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Bioinformat & Computat Biol, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Med, One Baylor Plaza MS305, Houston, TX 77030 USA

来源：

DEVELOPMENTAL DYNAMICS | 2018年 / 247卷 / 03期

基金：

美国国家卫生研究院;

关键词：

EMT; TCGA; Pan-cancer; NOTCH SIGNALING PATHWAY; PD-L1; EXPRESSION; EMT; METASTASIS; PLASTICITY; PROMOTES; FAMILY; LANDSCAPE; BLOCKADE; INVASION;

D O I：

10.1002/dvdy.24485

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Background: While epithelial-mesenchymal transition (EMT) can be readily induced experimentally in cancer cells, the EMT process as manifested in human tumors needs to be better understood. Pan-cancer genomic datasets from The Cancer Genome Atlas (TCGA), representing over 10,000 patients and 32 distinct cancer types, provide a rich resource for examining correlative patterns involving EMT mediators in the setting of human cancers. Results: Here, we surveyed a 16-gene signature of canonical EMT markers in TCGA pan-cancer cohort. The histology or cell-of-origin of a tumor sample may align more with mesenchymal or epithelial phenotype, and noncancer as well as cancer cells can contribute to the overall molecular patterns observed within a tumor sample; correlation models involving EMT markers can factor in both of the above variables. EMT-associated genes appear coordinately expressed across all cancers and within each cancer type surveyed. Gene signatures of immune cells correlate highly with EMT marker expression in tumors. In pan-cancer analysis, several EMT-related genes can be significantly associated with worse patient outcome. Conclusions: Gene correlates of EMT phenotype in human tumors could include novel mediators of EMT that might be confirmed experimentally, by which TCGA datasets may serve as a platform for discovery in ongoing studies. Developmental Dynamics 247:555-564, 2018. (c) 2017 Wiley Periodicals, Inc.

引用

页码：555 / 564

页数：10

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