Chrysin and its emerging role in cancer drug resistance

被引：19

作者：

Kasala, Eshvendar Reddy ^{[1
]}

Bodduluru, Lakshmi Narendra ^{[1
]}

Barua, Chandana C. ^{[2
]}

Gogoi, Ranadeep ^{[3
]}

机构：

[1] Natl Inst Pharmaceut Educ & Res, Dept Pharmacol & Toxicol, Gauhati 781032, Assam, India

[2] Assam Agr Univ, Coll Vet Sci, Dept Pharmacol & Toxicol, Gauhati 781022, Assam, India

[3] Natl Inst Pharmaceut Educ & Res, Dept Biotechnol, Gauhati 781032, Assam, India

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2015年 / 236卷

关键词：

Cisplatin; Chrysin; Apoptosis; Cancer therapy; Drug resistance; CELLS; FLAVONOIDS; CISPLATIN;

D O I：

10.1016/j.cbi.2015.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This letter illustrates the significant chemosensitizing effects of chrysin to resistance cancer cells and refers to the article on "Combination of chrysin and cisplatin promotes the apoptosis of Hep G2 cells by up-regulating p53" by Li et al., published in your journal recently. Recent studies have demonstrated that chrysin is able to sensitize or kill cancer cells which are resistant to chemotherapeutic drugs such as cisplatin, doxorubicin and adriamycin. Owing to its potential anti-cancer effects and devoid of toxicity to non-transformed cells, further research is required to completely explore its chemosensitizing effects in other cancers and also assess and evaluate its safety, before going for possible human application. (C) 2015 Elsevier Ireland Ltd. All rights reserved.

引用

页码：7 / 8

页数：2