Endoplasmic Reticulum Stress in Skeletal Muscle: Origin and Metabolic Consequences

被引：53

作者：

Deldicque, Louise ^{[1
]}

Hespel, Peter ^{[1
]}

Francaux, Marc ^{[2
]}

机构：

[1] Katholieke Univ Leuven, Dept Biomed Kinesiol, Res Ctr Exercise & Hlth, Louvain, Belgium

[2] Catholic Univ Louvain, Inst Neurosci, B-1348 Louvain, Belgium

来源：

EXERCISE AND SPORT SCIENCES REVIEWS | 2012年 / 40卷 / 01期

关键词：

unfolded protein response; XBP1; ATF6; IRE1; exercise; high-fat feeding; UNFOLDED PROTEIN RESPONSE; INSULIN SENSITIVITY; ER STRESS; EXPRESSION; PATHWAY; INFLAMMATION; RESISTANCE; EXERCISE; DISEASE; MEN;

D O I：

10.1097/JES.0b013e3182355e8c

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

DELDICQUE, L., P. HESPEL, and M. FRANCAUX. Endoplasmic reticulum stress in skeletal muscle: origin and metabolic consequences. Exerc. Sport Sci. Rev., Vol. 40, No. 1, pp. 43-49, 2012. In secretory organs, such as the liver, the pancreas, and the adipose tissue, endoplasmic reticulum (ER) stress plays a key role in the etiology of cell disturbances implicated in many diseases. Although much less studied, ER stress also is present in skeletal muscle. In the present review, we hypothesize that ER stress may have important metabolic consequences in skeletal muscle. This review presents the situations in which ER stress is activated in skeletal muscle and its metabolic consequences.

引用

页码：43 / 49

页数：7

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