Age-related changes in the DNA and RNA content of the brain in spontaneously hypertensive rats

被引：1

作者：

Nakane, H ^{[1
]}

Nakahara, T ^{[1
]}

Yao, H ^{[1
]}

Ooboshi, H ^{[1
]}

Ibayashi, S ^{[1
]}

Uchimura, H ^{[1
]}

Fujishima, M ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC SCI,DEPT CHEM,FUKUOKA 812,JAPAN

来源：

NEUROCHEMICAL RESEARCH | 1997年 / 22卷 / 03期

关键词：

aging; DNA; RNA; brain; SHR; HPLC;

D O I：

10.1023/A:1022478419450

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To elucidate the effects of aging accompanied with hypertension on brain nucleic acid, we measured both the DNA and RNA contents of six specific brain regions in adult (5-6 months old) and aged (18-22 months old) female spontaneously hypertensive rats (SHRs). Although no statistical difference was observed in the RNA content, the DNA content did tend to increase in the hippocampal CAI of aged SHR (4.24 +/- 0.55 ng/mu g protein, mean +/- SD, n = 6) in comparison to that of adult SHR (3.21 +/- 0.71 ng/mu g protein, n = 4). Hence, aged SHRs showed a significant decrease in the RNA to DNA ratio in the CA1 subfield of the hippocampus (3.79 +/- 0.61) compared to adult SHR (5.27 +/- 0.81). On the other hand, no other regions, except for the dorsolateral region of the striatum, showed any difference in the RNA/DNA ratio between aged and adult SHR. We therefore conclude that subtle changes in the nucleic acid occur in vulnerable regions of the brain in aged SHRs.

引用

页码：253 / 256

页数：4

共 28 条

[1] SCANNING-INTEGRATING MICRODENSITOMETRIC ANALYSIS OF AGE-RELATED-CHANGES IN RNA-CONTENT OF CEREBROCORTICAL NEURONS IN MICE SUBJECTED TO AUDITORY-STIMULATION [J].