Caffeic Acid Phenethyl Ester Protects Kidneys against Acetylsalicylic Acid Toxicity in Rats

被引：7

作者：

Bozkurt, Yasar ^{[1
]}

Bozkurt, Mehtap ^{[2
]}

Turkcu, Gul ^{[3
]}

Sancaktutar, Ahmet Ali ^{[1
]}

Soylemez, Haluk ^{[1
]}

Penbegul, Necmettin ^{[1
]}

Atar, Murat ^{[1
]}

Bodakci, Mehmet Nuri ^{[1
]}

Hatipoglu, Namik Kemal ^{[1
]}

Yuksel, Hatice ^{[4
]}

Kibrisli, Erkan ^{[5
]}

Yavuz, Celal ^{[6
]}

机构：

[1] Dicle Univ, Dept Urol, Fac Med, Diyarbakir, Turkey

[2] Dicle Univ, Dept Phys Med & Rehabil, Fac Med, Diyarbakir, Turkey

[3] Dicle Univ, Dept Pathol, Fac Med, Diyarbakir, Turkey

[4] Dicle Univ, Dept Biochem, Fac Med, Diyarbakir, Turkey

[5] Dicle Univ, Dept Family Phys, Fac Med, Diyarbakir, Turkey

[6] Dicle Univ, Dept Cardiovasc Surg, Fac Med, Diyarbakir, Turkey

来源：

RENAL FAILURE | 2012年 / 34卷 / 09期

关键词：

caffeic acid phenethyl ester; acetylsalicylic acid; kidney; rats; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ISCHEMIA-REPERFUSION INJURY; OXIDATIVE STRESS; MOUSE SKIN; CELLS; CAPE; POPULATION; APOPTOSIS; PROPOLIS; ASPIRIN;

D O I：

10.3109/0886022X.2012.717485

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Aim: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on acetylsalicylic acid (ASA)-induced renal damage in rats. Materials and methods: A total of 40 rats were randomly divided into five groups, with eight rats in each group-group 1: control, not receiving any medication; group 2: ASA (50 mg/kg/day); group 3: ASA (50 mg/kg/day) + CAPE (20 mu g/kg/day); group 4: ASA (100 mg/kg/day); and group 5: ASA (100 mg/kg/day) + CAPE (20 mu g/kg/day). ASA and CAPE were given via orogastric gavage for 5 days. The total oxidant status (TOS), total antioxidant capacity (TAC), and paraoxonase-1 (PON-1) activity of the blood samples and kidney tissues were determined. Histopathological examinations of the kidneys were performed using light microscopic methods. Results: The TOS level in the serum of rats and kidney tissues given ASA (groups 2 and 4) significantly increased, but the levels of TAC and PON-1 in these tissues significantly decreased in group 4 when compared with the control rats (p < 0.05). The levels of TAC and PON-1 in the kidney tissues increased and the levels of TOS decreased in the CAPE treatment groups (groups 3 and 5) when compared with the rats in the no CAPE treatment groups (groups 2 and 4). The PON-1, TAC, and TOS values reverted to normal levels in group 5 when compared to group 4 (p < 0.05). These results were supported by histopathological observation. Conclusion: Oxidative stress plays an important role in ASA-induced nephrotoxicity, and CAPE may protect against ASA-induced nephrotoxicity in rats.

引用

页码：1150 / 1155

页数：6

共 28 条

[11] NONSTEROIDAL ANTIINFLAMMATORY DRUGS CAUSE APOPTOSIS AND INDUCE CYCLOOXYGENASES IN CHICKEN-EMBRYO FIBROBLASTS [J].