Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

被引：177
作者：
Todd, JA [1 ]
Wicker, LS [1 ]
机构：
[1] Univ Cambridge, Inst Med Res, Wellcome Trust Diabet & Inflammat Lab, Juvenile Diabet Res Fdn, Cambridge CB2 2XY, England
来源：
IMMUNITY | 2001年 / 15卷 / 03期
基金：
英国惠康基金;
关键词：
D O I：
10.1016/S1074-7613(01)00202-3
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Populations of humans and mice contain alleles at many loci that protect from immune-mediated diseases. Identification of these alleles, some which are likely to function in immune recognition, tolerance, and regulation, will facilitate the development of diagnostics as well as therapeutics that alter disease progression.
引用
收藏
页码：387 / 395
页数：9
相关论文
共 78 条
[1]   Association of CTLA-4 but not CD28 gene polymorphisms with systemic lupus erythematosus in the Japanese population [J].
Ahmed, S ;
Ihara, K ;
Kanemitsu, S ;
Nakashima, H ;
Otsuka, T ;
Tsuzaka, K ;
Takeuchi, T ;
Hara, T .
RHEUMATOLOGY, 2001, 40 (06) :662-667
[2]   INSULIN-DEPENDENT DIABETES-MELLITUS AS AN AUTOIMMUNE-DISEASE [J].
BACH, JF .
ENDOCRINE REVIEWS, 1994, 15 (04) :516-542
[3]   Human type 1 diabetes and the insulin gene: Principles of mapping polygenes [J].
Bennett, ST ;
Todd, JA .
ANNUAL REVIEW OF GENETICS, 1996, 30 :343-370
[4]   Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand [J].
Bielekova, B ;
Goodwin, B ;
Richert, N ;
Cortese, I ;
Kondo, T ;
Afshar, G ;
Gran, B ;
Eaton, J ;
Antel, J ;
Frank, JA ;
McFarland, HF ;
Martin, R .
NATURE MEDICINE, 2000, 6 (10) :1167-1175
[5]  
Bonifacio E, 1999, J IMMUNOL, V163, P525
[6]  
Brayer J, 2000, J RHEUMATOL, V27, P1896
[7]   Protection against diabetes and improved NW/NKT cell performance in NOD.NK1.1 mice congenic at the NK complex [J].
Carnaud, C ;
Gombert, JM ;
Donnars, O ;
Garchon, HJ ;
Herbelin, A .
JOURNAL OF IMMUNOLOGY, 2001, 166 (04) :2404-2411
[8]   A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus [J].
Concannon, P ;
Gogolin-Ewens, KJ ;
Hinds, DA ;
Wapelhorst, B ;
Morrison, VA ;
Stirling, B ;
Mitra, M ;
Farmer, J ;
Williams, SR ;
Cox, NJ ;
Bell, GI ;
Risch, N ;
Spielman, RS .
NATURE GENETICS, 1998, 19 (03) :292-296
[9]  
Cordell HJ, 2001, GENETICS, V158, P357
[10]   A male-female bias in type 1 diabetes and linkage to chromosome Xp in MHC HLA-DR3-positive patients [J].
Cucca, F ;
Goy, JV ;
Kawaguchi, Y ;
Esposito, L ;
Merriman, ME ;
Wilson, AT ;
Cordell, HJ ;
Bain, SC ;
Todd, JA .
NATURE GENETICS, 1998, 19 (03) :301-302
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