Interlinked fast and slow positive feedback loops drive reliable cell decisions

被引：346

作者：

Brandman, O ^{[1
]}

Ferrett, JE

Li, R

Meyer, T

机构：

[1] Stanford Univ, Sch Med, Dept Mol Pharmacol, Stanford, CA 94305 USA

[2] Marine Biol Lab, Physiol Course 2004, Woods Hole, MA 02543 USA

[3] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

[4] Stowers Inst Med Res, Kansas City, MO 64110 USA

来源：

SCIENCE | 2005年 / 310卷 / 5747期

关键词：

D O I：

10.1126/science.1113834

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Positive feedback is a ubiquitous signal transduction motif that allows systems to convert graded inputs into decisive, all-or-none outputs. Here we investigate why the positive feedback switches that regulate polarization of budding yeast, calcium signaling, Xenopus oocyte maturation, and various other processes use multiple interlinked loops rather than single positive feedback loops. Mathematical simulations revealed that linking fast and stow positive feedback loops creates a "dual-time" switch that is both rapidly inducible and resistant to noise in the upstream signaling system.

引用

页码：496 / 498

页数：3

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