ANXIOLYTIC-LIKE, STIMULANT AND NEUROPROTECTIVE EFFECTS OF ILEX PARAGUARIENSIS EXTRACTS IN MICE

被引：28

作者：

Santos, E. C. S. ^{[1
]}

Bicca, M. A. ^{[1
]}

Blum-Silva, C. H. ^{[2
]}

Costa, A. P. R. ^{[1
]}

Dos Santos, A. A. ^{[3
]}

Schenkel, E. P. ^{[2
]}

Farina, M. ^{[3
]}

Reginatto, F. H. ^{[2
]}

De Lima, T. C. M. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Ctr Biol Sci, Dept Pharmacol, BR-88040970 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Ctr Ciencias Farmaceut, Dept Ciencias Farmaceut, BR-88040970 Florianopolis, SC, Brazil

[3] Univ Fed Santa Catarina, Ctr Ciencias Biol, Dept Bioquim, BR-88040970 Florianopolis, SC, Brazil

来源：

NEUROSCIENCE | 2015年 / 292卷

关键词：

anxiety; Ilex paraguariensis; stimulant; caffeine; memory; ANIMAL-MODELS; CAFFEINE; MATE; ACETYLCHOLINESTERASE; ANTICONVULSANT; HIPPOCAMPUS; DYSFUNCTION; BEHAVIOR; ANXIETY;

D O I：

10.1016/j.neuroscience.2015.02.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Yerba-mate (Ilex paraguariensis St. Hil.) is the most used beverage in Latin America with approximately 426 thousand of tons consumed per year. Considering the broad use of this plant, we aimed to investigate the anxiety-like and stimulant activity of both the hydroethanolic (HE) and aqueous (AE) extracts from leaves of I. paraguariensis. Swiss mice were treated with I. paraguariensis HE or AE chronically or acutely, respectively, followed by evaluation in the elevated plus-maze (EPM; anxiety-like paradigm), open field (OF; locomotor activity) or the step-down avoidance task (memory assessment). Following behavioral protocols the brains were collected for evaluation of acetylcholinesterase (AChE) activity ex vivo. Chronic treatment with HE induced an anxiolytic-like effect and increased motor activity besides augmented AChE activity. Additionally, acute treatment with AE prevented the scopolamine-induced memory deficit in the step-down avoidance task. Overall, our results indicate the importance of the I. paraguariensis-induced CNS effects, since it is a widely used nutraceutical. We have reported anxiolytic, stimulant and neuroprotective effects for this plant species. These effects are potentially modulated by the cholinergic system as well as by caffeine. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：13 / 21

页数：9

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