Thrombotic microangiopathy induced by long-term interferon-β therapy for multiple sclerosis: a case report

被引：27
作者：
Broughton, A.
Cosyns, J. -P. [2 ]
Jadoul, M. [1 ]
机构：
[1] Catholic Univ Louvain, Clin Univ St Luc, Serv Nephrol, Dept Nephrol, B-1200 Brussels, Belgium
[2] Catholic Univ Louvain, Clin Univ St Luc, Dept Pathol, B-1200 Brussels, Belgium
来源：
CLINICAL NEPHROLOGY | 2011年 / 76卷 / 05期
关键词：
interferon; multiple sclerosis; micro-angiopathy; ANTIPHOSPHOLIPID ANTIBODIES; NEPHROTIC SYNDROME; ALPHA; LEUKEMIA; ASSOCIATION; PATIENT;
D O I：
10.5414/CN106523
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
We report the case of a 53-year-old woman treated for 8 years with Betaferon (R) (interferon-beta-1b), who developed mild renal failure with hypertension, proteinuria and glomerular hematuria. Kidney biopsy was consistent with thrombotic micro-angiopathy (TMA). Considering the strong evidence of interferon-alpha causing TMA and the numerous immunomodulatory activities shared by INF-alpha and -beta, we incriminated Betaferon as the etiological agent of TMA in our patient. To our knowledge, it is the first time such an association has been published.
引用
收藏
页码：396 / 400
页数：5
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