In sickness and in health: The functional role of extracellular vesicles in physiology and pathology in vivo Part I: Health and Normal Physiology

被引：135

作者：

Yates, Abi G. ^{[1
,2
]}

Pink, Ryan C. ^{[3
]}

Erdbrugger, Uta ^{[4
]}

Siljander, Pia R-M. ^{[5
]}

Dellar, Elizabeth R. ^{[3
]}

Pantazi, Paschalia ^{[3
]}

Akbar, Naveed ^{[6
]}

Cooke, William R. ^{[7
]}

Vatish, Manu ^{[7
]}

Dias-Neto, Emmanuel ^{[8
,9
]}

Anthony, Daniel C. ^{[1
]}

Couch, Yvonne ^{[10
]}

机构：

[1] Univ Oxford, Dept Pharmacol, Oxford, England

[2] Univ Queensland, Fac Med, Sch Biomed Sci, St Lucia, Qld, Australia

[3] Oxford Brookes Univ, Fac Hlth & Life Sci, Dept Biol & Med Sci, Headington Campus, Oxford, England

[4] Univ Virginia, Dept Med, Div Nephrol, Charlottesville, VA USA

[5] Univ Helsinki, Fac Biol & Environm Sci, Mol & Integrat Biosci Res Programme, Helsinki, Finland

[6] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England

[7] Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Oxford, England

[8] AC Camargo Canc Ctr, Lab Med Genom, Sao Paulo, Brazil

[9] Sao Paulo Med Sch, Inst Psychiat, Lab Neurosci LIM 27, Sao Paulo, Brazil

[10] Univ Oxford, John Radcliffe Hosp, Acute Stroke Programme, Radcliffe Dept Med, Oxford OX3 9DU, England

来源：

JOURNAL OF EXTRACELLULAR VESICLES | 2022年 / 11卷 / 01期

基金：

芬兰科学院; 巴西圣保罗研究基金会;

关键词：

exosomes; extracellular vesicles; in vivo; microvesicles; pathology; physiology; SKELETAL-MUSCLE; ACTIVATED PLATELETS; DENDRITIC CELLS; ADENOSINE-TRIPHOSPHATASE; MATERNAL CIRCULATION; EMERGING ROLE; HUMAN PLASMA; FAS LIGAND; T-CELLS; EXOSOMES;

D O I：

10.1002/jev2.12151

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Previously thought to be nothing more than cellular debris, extracellular vesicles (EVs) are now known to mediate physiological and pathological functions throughout the body. We now understand more about their capacity to transfer nucleic acids and proteins between distant organs, the interaction of their surface proteins with target cells, and the role of vesicle-bound lipids in health and disease. To date, most observations have been made in reductionist cell culture systems, or as snapshots from patient cohorts. The heterogenous population of vesicles produced in vivo likely act in concert to mediate both beneficial and detrimental effects. EVs play crucial roles in both the pathogenesis of diseases, from cancer to neurodegenerative disease, as well as in the maintenance of system and organ homeostasis. This two-part review draws on the expertise of researchers working in the field of EV biology and aims to cover the functional role of EVs in physiology and pathology. Part I will outline the role of EVs in normal physiology.

引用

页数：19

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