Photovoltaic restoration of sight with high visual acuity

被引：256

作者：

Lorach, Henri ^{[1
,2
,3
]}

Goetz, Georges ^{[1
,4
]}

Smith, Richard ^{[5
]}

Lei, Xin ^{[4
]}

Mandel, Yossi ^{[6
]}

Kamins, Theodore ^{[4
]}

Mathieson, Keith ^{[7
]}

Huie, Philip ^{[1
,2
]}

Harris, James ^{[4
]}

Sher, Alexander ^{[5
]}

Palanker, Daniel ^{[1
,2
]}

机构：

[1] Stanford Univ, Hansen Expt Phys Lab, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Ophthalmol, Stanford, CA 94305 USA

[3] INSERM, Inst Vis, UMR S968, Paris, France

[4] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[5] Univ Calif Santa Cruz, Santa Cruz Inst Particle Phys, Santa Cruz, CA 95064 USA

[6] Bar Ilan Univ, Mina & Everard Goodman Fac Life Sci, IL-52100 Ramat Gan, Israel

[7] Univ Strathclyde, Inst Photon, Glasgow, Lanark, Scotland

来源：

NATURE MEDICINE | 2015年 / 21卷 / 05期

基金：

美国国家卫生研究院;

关键词：

RETINAL GANGLION-CELLS; CONTRAST SENSITIVITY; RAT; FREQUENCY; PROSTHESIS; RESOLUTION; SYSTEM; MODEL;

D O I：

10.1038/nm.3851

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Patients with retinal degeneration lose sight due to the gradual demise of photoreceptors. Electrical stimulation of surviving retinal neurons provides an alternative route for the delivery of visual information. We demonstrate that subretinal implants with 70-mm-wide photovoltaic pixels provide highly localized stimulation of retinal neurons in rats. The electrical receptive fields recorded in retinal ganglion cells were similar in size to the natural visual receptive fields. Similarly to normal vision, the retinal response to prosthetic stimulation exhibited flicker fusion at high frequencies, adaptation to static images and nonlinear spatial summation. In rats with retinal degeneration, these photovoltaic arrays elicited retinal responses with a spatial resolution of 64 +/- 11 mu m, corresponding to half of the normal visual acuity in healthy rats. The ease of implantation of these wireless and modular arrays, combined with their high resolution, opens the door to the functional restoration of sight in patients blinded by retinal degeneration.

引用

页码：476 / U254

页数：10

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